Trimerization of HA

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Influenza A virus
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Trimerisation of the fully folded and fully oxidised HA monomer is thought to occur in the endoplasmic reticulum and ERGIC compartment, following dissociation of HA from calnexin. Trimerisation is generally thought to be the final step in HA maturation occurring in the endoplasmic reticulum before transport to the Golgi apparatus, although Yewdell et al (1988) provide data suggesing that trimerisation may occur within the Golgi.

Literature References
PubMed ID Title Journal Year
8460475 Folding and assembly of viral membrane proteins

Doms, RW, Helenius, A, Lamb, RA, Rose, JK

Virology 1993
7729412 Folding and oligomerization of influenza hemagglutinin in the ER and the intermediate compartment

Hammond, C, Helenius, A, Tatu, U

EMBO J 1995
3757030 Expression of wild-type and mutant forms of influenza hemagglutinin: the role of folding in intracellular transport

Sambrook, J, Gething, MJ, McCammon, K

Cell 1986
Event Information
Go Biological Process
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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