Association of HA into rafts

Stable Identifier
R-HSA-168862
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
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Influenza virus buds preferentially from lipid rafts (Scheiffele et al, 1999). NA protein individually accumulates at, and is selectively incorporated into rafts (Kundu et al., 1996). The signals for raft association lie within the transmembranse domain (TMD), (Barman et al., 2001, Barman et al., 2004), and raft association of NA has been shown to be essential for efficient virus replication. This is believed to be due to a requirement for a concentration of NA at specific areas of the plasma membrane to support a level of NA incorporation into budding particles sufficient to allow for efficient virus release (Barman et al., 2004).

Literature References
PubMed ID Title Journal Year
9312009 Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain

Scheiffele, P, Roth, MG, Simons, K

EMBO J 1997
14561897 Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion

Takeda, M, Leser, GP, Russell, CJ, Lamb, RA

Proc Natl Acad Sci U S A 2003
Participants
Participant Of
Event Information
Go Biological Process
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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