Palmitoylation of cysteine residues on HA in the cis-Golgi network

Stable Identifier
R-HSA-168858
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
Golgi membrane
ReviewStatus
5/5
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Palmitoylation of cysteine residues on HA in the cis-Golgi network
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The hemagglutinin of influenza virus is palmitoylated with long-chain fatty acids.
Palmitoylation of HA is believed to occur in the cis golgi network (Veit 1993), shortly after trimerisation of the molecule, and before cleavage of the HA into HA1 and HA2. HA is palmitoylated through thioester linkages at three cysteine residues located in the cytoplasmic domain and at the carboxy-terminal end of the transmembrane region. Lack of acylation has no obvious influence on the biological activities of HA.
Literature References
PubMed ID Title Journal Year
1901916 Site-specific mutagenesis identifies three cysteine residues in the cytoplasmic tail as acylation sites of influenza virus hemagglutinin

Kuroda, K, Klenk, HD, Garten, W, Kretzschmar, E, Veit, M, Rott, R, Schmidt, MF

J Virol 1991
8262238 Timing of palmitoylation of influenza virus hemagglutinin

Veit, M, Schmidt, MF

FEBS Lett 1993
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Output
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as an event of
Event Information
Go Biological Process
viral protein processing (0019082)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Steel, J  (2007-05-01)
Reviewed
Squires, B  (2007-05-01)
Rush, MG  (2007-05-01)
Created
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