tBID binds to inactive BAK protein

Stable Identifier
R-HSA-168848
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
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tBID binds to inactive BAK protein
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tBID binds to its mitochondrial partner BAK to release cytochrome c. It has been observed in mouse systems that the activated tBID results in an allosteric activation of BAK. Activated BAK induces intramembranous oligomerization leading to a pore for cytochrome c efflux (Wei et al. 2000).

Literature References
PubMed ID Title Journal Year
10950869 tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Lindsten, T, Wei, MC, Gross, A, Mootha, VK, Korsmeyer, SJ, Thompson, CB, Ashiya, M, Weiler, S

Genes Dev 2000
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Orthologous Events
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Created
Gopinathrao, G  (2005-11-19)
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