tBID binds to inactive BAK protein

Stable Identifier
Reaction [binding]
Homo sapiens
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tBID binds to its mitochondrial partner BAK to release cytochrome c. It has been observed in mouse systems that the activated tBID results in an allosteric activation of BAK. Activated BAK induces intramembranous oligomerization leading to a pore for cytochrome c efflux (Wei et al. 2000).

Literature References
PubMed ID Title Journal Year
10950869 tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Wei, MC, Lindsten, T, Mootha, VK, Weiler, S, Gross, A, Ashiya, M, Thompson, CB, Korsmeyer, SJ

Genes Dev 2000
Participant Of
Orthologous Events
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