Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane

Stable Identifier
R-HSA-168312
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
endocytic vesicle membrane, endosome lumen
ReviewStatus
5/5
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Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane
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The fusion peptide of its HA2 subunit interacts with the endosome membrane. The transmembrane domain of the HA2 is inserted into the viral membrane and the fusion peptide is inserted into the endosomal membrane. In the acidic pH structure of HA the two ends of the HA complex are in juxtaposition.
Literature References
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
fusion of virus membrane with host plasma membrane (0019064)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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