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Go!
Budding
Stable Identifier
R-HSA-168302
Type
Pathway
Species
Homo sapiens
Related Species
Influenza A virus
ReviewStatus
5/5
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Budding (Homo sapiens)
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The process by which influenza virus particles bud from an infected cell is not very well understood. Accumulation of M1 at the inner leaflet of the plasma membrane is thought to be the trigger for the initiation of bud formation. This bud formation continues until the inner core of the virus is completely enveloped. Completion of the budding process requires the membrane at the base of the bud to fuse. Although M1 is thought to be the driving force for bud formation, other viral and cellular proteins have been demonstrated to affect size and shape of the virus particle. Generally, influenza virus particles are either spherical or filamentous and this characteristic morphology is genetically linked to the M segment (Bourmakina, 2003; Roberts, 1998). Host factors such as polarization and the actin cytoskeleton play a critical role in determining the shape of filamentous particles (Roberts, 1998; Simpson-Holley, 2002).
Literature References
PubMed ID
Title
Journal
Year
16139601
Influenza virus assembly and budding at the viral budozone
Schmitt, AP
,
Lamb, RA
Adv Virus Res
2005
15567494
Assembly and budding of influenza virus
Barman, S
,
Nayak, DP
,
Hui, EK
Virus Res
2004
Participants
Events
Membrane fusion
(Homo sapiens)
Participates
as an event of
Virus Assembly and Release (Homo sapiens)
Event Information
Go Biological Process
virion assembly (0019068)
Disease
Name
Identifier
Synonyms
influenza
DOID:8469
Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Marsh, G (2007-05-01)
Reviewed
Squires, B (2007-05-01)
Rush, MG (2007-05-01)
Created
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