Release

Stable Identifier
R-HSA-168298
Type
Pathway
Species
Homo sapiens
Related Species
Influenza A virus
ReviewStatus
5/5
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Release
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Once the viral envelope has separated from the cell membrane Influenza virus particles are actively released to complete the budding process. HA (hemagglutinin) anchors the virus to the cell by binding to sialic acid-containing receptors on the cell surface. The enzymatic activity of the neuraminidase (NA) protein removes the sialic acid and releases the virus from the host cell. NA activity is also required to remove sialic acid from the carbohydrates present on the viral glycoproteins to prevent the viral particles from aggregating.

Literature References
PubMed ID Title Journal Year
16139601 Influenza virus assembly and budding at the viral budozone

Schmitt, AP, Lamb, RA

Adv Virus Res 2005
15567494 Assembly and budding of influenza virus

Barman, S, Nayak, DP, Hui, EK

Virus Res 2004
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
viral release from host cell (0019076)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Marsh, G  (2007-05-01)
Reviewed
Squires, B  (2007-05-01)
Rush, MG  (2007-05-01)
Created
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