Reactome | Toll Like Receptor TLR1:TLR2 Cascade

Toll Like Receptor TLR1:TLR2 Cascade

Stable Identifier

R-HSA-168179

Type

Pathway

Species

Homo sapiens

Related Species

Chlamydia trachomatis, Neisseria meningitidis serogroup B

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others, triggering up-regulation of nuclear factor-kappaB production and apoptotic cascades. Such cooperation between TLR1 and TLR2 on the cell surface of normal human peripheral blood mononuclear cells, for instance, leads to the activation of pro-inflammatory cytokine secretion (Sandor et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12975352	Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling Latz, E, Mandell, L, Re, F, Repik, G, Finberg, RW, Golenbock, DT, Kurt-Jones, EA, Sandor, F, Espevik, T	J Cell Biol	2003