Reactome | Toll Like Receptor TLR1:TLR2 Cascade

Toll Like Receptor TLR1:TLR2 Cascade

Stable Identifier

R-HSA-168179

Type

Pathway

Species

Homo sapiens

Related Species

Neisseria meningitidis serogroup B, Chlamydia trachomatis

ReviewStatus

5/5

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TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others, triggering up-regulation of nuclear factor-kappaB production and apoptotic cascades. Such cooperation between TLR1 and TLR2 on the cell surface of normal human peripheral blood mononuclear cells, for instance, leads to the activation of pro-inflammatory cytokine secretion (Sandor et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12975352	Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling Sandor, F, Latz, E, Re, F, Mandell, L, Repik, G, Golenbock, DT, Espevik, T, Kurt-Jones, EA, Finberg, RW	J Cell Biol	2003