Reactome | Toll Like Receptor 10 (TLR10) Cascade

Toll Like Receptor 10 (TLR10) Cascade

Stable Identifier

R-HSA-168142

Type

Pathway

Species

Homo sapiens

Related Species

Escherichia coli

ReviewStatus

5/5

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Little is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may also heterodimerize with TLRs 1 and 2. It is expressed in a restricted fashion as a highly N-glycosylated protein detectable in B cells and dendritic cells.

Literature References

PubMed ID	Title	Journal	Year
15728506	Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88 Merck, E, Chaffois, C, Trinchieri, G, Vlach, J, Saulnier, V, Hasan, U, Lebecque, S, Briere, F, Bates, EE, Tancredi, S, Guiet, C, Gaillard, C	J Immunol	2005
18332149	The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer Hammarström, M, Johansson, I, Nordlund, P, Stenmark, P, Flodin, S, Nyman, T	J Biol Chem	2008