Reactome | ECSIT [cytosol]

ECSIT [cytosol]

Stable Identifier

R-HSA-168064

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

evolutionarily conserved signaling intermediate in Toll pathway

Locations in the PathwayBrowser for interactor UniProt:Q92633 LPAR1

Expand all

External Reference Information

External Reference

UniProt:Q9BQ95 ECSIT

Gene Names

ECSIT

Chain

transit peptide:1-48, chain:49-431

Reference Genes

BioGPS Gene:51295 ECSIT

COSMIC (genes):ECSIT ECSIT

CTD Gene:51295 ECSIT

dbSNP Gene:51295 ECSIT

ENSEMBL:ENSG00000130159 ECSIT

ENSEMBL_homo_sapiens_GENE:ENSG00000130159.15 ECSIT

HGNC:29548 ECSIT

KEGG Gene (Homo sapiens):51295 ECSIT

Monarch:51295 ECSIT

NCBI Gene:51295 ECSIT

OMIM:608388 ECSIT

UCSC:Q9BQ95 ECSIT

Reference Transcript

Other Identifiers

11718417_a_at

16869006

218225_PM_at

218225_at

3851013

3851014

3851015

3851017

3851019

3851021

3851022

3851023

3851025

3851027

3851028

3851031

3851036

3851037

3851041

3851047

3851048

49013_at

51295

8034286

A_23_P119295

GE55010

GO:0002376

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005743

GO:0005829

GO:0007005

GO:0007178

GO:0023052

GO:0032981

GO:0034142

GO:0043226

GO:0045087

GO:0051341

GO:0060090

GO:0061635

GO:0065003

GO:0098542

HMNXSV003039252

ILMN_2233604

PH_hs_0001937

TC19002336.hg

TC19002679.hg

g7706114_3p_at

This entity regulates

Positively

TRAF6 binds MEKK1 (Homo sapiens)

Other forms of this molecule

ECSIT [mitochondrial inner membrane]

Inferred To

ECSIT [cytosol] (Bos taurus)

ECSIT [cytosol] (Canis familiaris)

ECSIT [cytosol] (Gallus gallus)

ECSIT [cytosol] (Sus scrofa)

ecsit [cytosol] (Xenopus tropicalis)

Ecsit [cytosol] (Mus musculus)

Ecsit [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_057665.2, NP_001135937.1, NP_001230133.1, NP_001135936.1

OpenTargets

ENSG00000130159

HPA

ENSG00000130159-ECSIT

GeneCards

Q9BQ95

Ensembl

ENST00000591104, ENST00000417981, ENSP00000252440, ENST00000688351, ENSP00000466559, ENSG00000130159, ENSP00000510792, ENST00000690346, ENSP00000412712, ENST00000270517, ENSP00000270517, ENST00000252440, ENSP00000508502

PRO

Q9BQ95

Pharos - Targets

Q9BQ95

HMDB Protein

HMDBP08887

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H845 ACAD9	1	ACAD9 [mitochondrial inner membrane] (R-HSA-5689049)	0.725	5
UniProt:Q9Y375 NDUFAF1	1	NDUFAF1 [mitochondrial inner membrane] (R-HSA-5689050)	0.643	5
UniProt:Q9P0J0 NDUFA13	8	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936) NDUFA13(41-49) [mitochondrial inner membrane] (R-HSA-9839958) NDUFA13(100-108) [mitochondrial inner membrane] (R-HSA-9839959) NDUFA13(109-144) [mitochondrial inner membrane] (R-HSA-9839968) NDUFA13(2-19) [mitochondrial inner membrane] (R-HSA-9839966) NDUFA13(69-99) [mitochondrial inner membrane] (R-HSA-9839964) NDUFA13(20-40) [mitochondrial inner membrane] (R-HSA-9839963) NDUFA13(50-68) [mitochondrial inner membrane] (R-HSA-9839961)	0.643	4
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.643	5
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.643	3
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.643	5
UniProt:P03905 MT-ND4	1	MT-ND4 [mitochondrial inner membrane] (R-HSA-60561)	0.643	3
UniProt:Q9BQP7 MGME1			0.643	3
UniProt:P49768 PSEN1	6	PSEN1(1-467) [plasma membrane] (R-HSA-201606) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(299-467) [plasma membrane] (R-HSA-2534245)	0.582	4
UniProt:Q9NX04 AIRIM			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.556	3
UniProt:A2RTX5 SYTC2			0.556	3
UniProt:Q9UI47-2 CTNNA3			0.556	3
UniProt:Q96PN8 TSSK3			0.556	3
UniProt:Q13515 BFSP2			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:O15479 MAGB2			0.556	3
UniProt:Q9Y2H9 MAST1			0.547	2
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2
UniProt:Q9NY25 CLEC5A	3	CLEC5A [specific granule membrane] (R-HSA-6799520) CLEC5A [tertiary granule membrane] (R-HSA-6801019) CLEC5A [plasma membrane] (R-HSA-210028)	0.527	2
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	4
UniProt:P30153 PPP2R1A	2	PPP2R1A [nucleoplasm] (R-HSA-165968) PPP2R1A [cytosol] (R-HSA-165982)	0.527	3
UniProt:O00217 NDUFS8	1	NDUFS8 [mitochondrial matrix] (R-HSA-6788526)	0.527	2
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.527	2
UniProt:Q9P032 NDUFAF4	1	NDUFAF4 [mitochondrial inner membrane] (R-HSA-5689124)	0.527	3
UniProt:Q96CS3 FAF2	3	FAF2 [cytosol] (R-HSA-6781921) FAF2 [extracellular region] (R-HSA-6806183) FAF2 [azurophil granule lumen] (R-HSA-6799138)	0.527	2
UniProt:Q9Y285 FARSA	1	FARSA [cytosol] (R-HSA-379667)	0.527	2
UniProt:Q9NPY3 CD93	5	CD93 [specific granule membrane] (R-HSA-6801410) CD93 [ficolin-1-rich granule membrane] (R-HSA-6801408) CD93 [secretory granule membrane] (R-HSA-6806155) CD93 [plasma membrane] (R-HSA-6801600) CD93 [tertiary granule membrane] (R-HSA-6801403)	0.527	2
UniProt:Q9NX14 NDUFB11	1	NDUFB11 [mitochondrial inner membrane] (R-HSA-163933)	0.527	2
UniProt:Q9H244 P2RY12	1	P2RY12 [plasma membrane] (R-HSA-391959)	0.527	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [azurophil granule membrane] (R-HSA-6799517) C3AR1 [specific granule membrane] (R-HSA-6799516)	0.527	2
UniProt:O95298 NDUFC2	3	NDUFC2 [plasma membrane] (R-HSA-6806276) NDUFC2 [azurophil granule membrane] (R-HSA-6799211) NDUFC2 [mitochondrial inner membrane] (R-HSA-59860)	0.527	3
UniProt:P51970 NDUFA8	1	NDUFA8 [mitochondrial inner membrane] (R-HSA-60627)	0.527	2
UniProt:Q8N4S9 MALD2			0.527	2
UniProt:P41587 VIPR2	1	VIPR2 [plasma membrane] (R-HSA-420227)	0.527	2
UniProt:Q8IUX1 TMEM126B	1	TMEM126B [mitochondrial inner membrane] (R-HSA-5689046)	0.527	3
UniProt:O95167 NDUFA3	1	NDUFA3 [mitochondrial inner membrane] (R-HSA-60180)	0.527	2
UniProt:O75438 NDUFB1	1	NDUFB1 [mitochondrial inner membrane] (R-HSA-60214)	0.527	2
UniProt:O95169 NDUFB8	4	NDUFB8 [mitochondrial inner membrane] (R-HSA-163938) NDUFB8(1-28) [mitochondrial matrix] (R-HSA-8986166) NDUFB8(1-186) [mitochondrial inner membrane] (R-HSA-8986184) NDUFB8(1-186) [mitochondrial intermembrane space] (R-HSA-8986140)	0.527	2
UniProt:P46199 MTIF2	1	MTIF2 [mitochondrial matrix] (R-HSA-5368271)	0.527	2
UniProt:O43674 NDUFB5	1	NDUFB5 [mitochondrial inner membrane] (R-HSA-163944)	0.527	3
UniProt:Q96C01 F136A			0.527	4
UniProt:Q92633 LPAR1	1	LPAR1 [plasma membrane] (R-HSA-419354)	0.527	3
UniProt:Q9GZY4 COA1	1	COA1 [mitochondrial inner membrane] (R-HSA-9708001)	0.527	2
UniProt:O43920 NDUFS5	1	NDUFS5 [mitochondrial inner membrane] (R-HSA-60226)	0.527	3
UniProt:Q12797 ASPH	2	ASPH [endoplasmic reticulum lumen] (R-HSA-9631383) ASPH [endoplasmic reticulum membrane] (R-HSA-5490331)	0.527	3
UniProt:P0DTD3 ORF9C			0.527	2
UniProt:P49810 PSEN2	2	PSEN2(1-297) [plasma membrane] (R-HSA-201599) PSEN2(298-448) [plasma membrane] (R-HSA-9013329)	0.524	4
UniProt:P02649 APOE	10	APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE-4 [extracellular region] (R-HSA-9711070) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [extracellular region] (R-HSA-174646) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908)	0.524	4

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