Reactome | TLR5 [plasma membrane]

TLR5 [plasma membrane]

Stable Identifier

R-HSA-168013

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Toll Like Receptor 5

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)
        
        TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR (Homo sapiens)
        
        IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (Homo sapiens)
        
        IRAK1 or IRAK2 :p-IRAK4:MyD88 oligomer:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        IRAK4 autophosphorylation within the complex activated TLR:MyD88 (Homo sapiens)
        
        IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor (Homo sapiens)
        
        IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR (Homo sapiens)
        
        hp-IRAK1:activated IRAK4:MyD88oligomer:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        MyD88 forms a complex with the activated TLR receptor (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        MyD88 complexed with the activated TLR5 or 10 receptor [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        MyD88 oligomerization within the complex of activated TLR:MyD88 (Homo sapiens)
        
        MyD88 complexed with the activated TLR5 or 10 receptor [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex (Homo sapiens)
        
        IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex (Homo sapiens)
        
        p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)
        
        TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - Flagellin binds to TLR5 (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)
        
        TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR (Homo sapiens)
        
        IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (Homo sapiens)
        
        IRAK1 or IRAK2 :p-IRAK4:MyD88 oligomer:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        IRAK4 autophosphorylation within the complex activated TLR:MyD88 (Homo sapiens)
        
        IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor (Homo sapiens)
        
        IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR (Homo sapiens)
        
        hp-IRAK1:activated IRAK4:MyD88oligomer:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        MyD88 forms a complex with the activated TLR receptor (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        MyD88 complexed with the activated TLR5 or 10 receptor [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        MyD88 oligomerization within the complex of activated TLR:MyD88 (Homo sapiens)
        
        MyD88 complexed with the activated TLR5 or 10 receptor [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex (Homo sapiens)
        
        IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex (Homo sapiens)
        
        p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)
        
        TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)
        
        hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
        
        p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
        
        Activated TLR5 or TLR10 homodimer [plasma membrane] (Homo sapiens)
        
        TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)
        
        TLR5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60602 TLR5

Gene Names

TLR5, TIL3

Chain

signal peptide:1-20, chain:21-858

Reference Genes

BioGPS Gene:7100 TLR5

COSMIC (genes):TLR5 TLR5

CTD Gene:7100 TLR5

dbSNP Gene:7100 TLR5

ENSEMBL:ENSG00000187554 TLR5

HGNC:11851 TLR5

KEGG:hsa:7100 TLR5

Monarch:7100 TLR5

NCBI Gene:7100 TLR5

OMIM:603031 TLR5

UCSC:O60602 TLR5

Reference Transcript

Other Identifiers

11731200_a_at

16699634

210166_PM_at

210166_at

2457692

2457693

2457694

2457695

2457696

2457699

2457700

2457701

2457702

2457705

34473_at

4045364

4045365

4045366

4045368

4045370

4045378

4045380

4045382

4045383

4045384

4045385

4045386

4045387

4045388

4045389

4045391

4045392

4045393

4045394

4045397

54586_at

7100

71591_at

7924499

A_23_P85903

A_33_P3263423

GE531889

GE54433

GE838488

GO:0002224

GO:0002376

GO:0004888

GO:0005149

GO:0005515

GO:0005886

GO:0006954

GO:0006955

GO:0007165

GO:0008584

GO:0016020

GO:0022414

GO:0032757

GO:0034146

GO:0038023

GO:0038187

GO:0045087

GO:0045429

GO:0048856

GO:0060089

GO:0071222

GO:0071260

GO:0098542

HMNXSV003000650

ILMN_1722981

PH_hs_0027781

TC01003871.hg

g3132525_3p_at

Participates

as an input of

Flagellin binds to TLR5 (Homo sapiens)

as a component of

TLR5 homodimer:bacterial flagellin [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_005273299.2, XP_011508239.1, NP_003259.2, XP_005273300.2, XP_006711568.1, XP_006711569.1, XP_006711567.1, XP_005273298.2, XP_016857697.1

Guide to Pharmacology - Targets

1755

OpenTargets

ENSG00000187554

ENSEMBL

ENST00000642603, ENSP00000496355

HPA

ENSG00000187554-TLR5

PRO

O60602

Pharos - Targets

O60602

GlyGen

O60602

PDB

3J0A, 8AR2

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067-PRO_0000000092 APP			0.558	3
UniProt:P05067-PRO_0000000093 APP			0.558	3
IntAct:EBI-14348029 ABETA-42-OLIGOMER			0.558	2
UniProt:O75911 DHRS3	2	DHRS3 [endoplasmic reticulum membrane] (R-HSA-5419172) DHRS3 [photoreceptor outer segment membrane] (R-HSA-2980986)	0.527	2
UniProt:Q9BT09 CNPY3	1	CNPY3 [endoplasmic reticulum lumen] (R-HSA-1678932)	0.527	2
UniProt:O60476 MAN1A2	2	MAN1A2 [transport vesicle] (R-HSA-8847486) MAN1A2 [Golgi membrane] (R-HSA-964747)	0.527	2
UniProt:Q9Y3E5 PTRH2	2	PTRH2 [mitochondrial outer membrane] (R-HSA-5696909) PolyUb-PTRH2 [mitochondrial outer membrane] (R-HSA-6783190)	0.527	2
UniProt:Q9BRX8 PXL2A			0.527	2
UniProt:O95476 CTDNEP1	1	CTDNEP1 [nuclear envelope] (R-HSA-3632863)	0.527	2

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