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What is Reactome ?
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Digital Preservation
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C-ter TLR7 dimer [endosome membrane]
Stable Identifier
R-HSA-1679575
Type
Complex
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
C-terminus TLR7 dimer
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
RSV ssRNA binds C-ter TLR7 dimer (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer: RSV ssRNA [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
C-ter TLR7 dimer binds HCQ (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
C-ter TLR7 dimer binds TLR7, TLR8 ligands (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
C-ter TLR7 dimer binds SARS-CoV-2 GU-rich ssRNA (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TLR7 dimer:SARS-CoV-2 ssRNA [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
C-ter TLR7 dimer binds HCQ (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer binds TLR7, TLR8 ligands (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer binds imiquimod (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:imiquimod [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
MyD88 interacts with the activated TLR receptor 7, 8 or 9 (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 (Homo sapiens)
MyD88 complexed with the activated TLR receptor [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (Homo sapiens)
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)
TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] (Homo sapiens)
oligo-MyD88:activated TLR7-9 [endosome membrane] (Homo sapiens)
Activated TLR7-9 homodimers [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer [endosome membrane] (Homo sapiens)
Participants
components
x 2
TLR7(?-1049) [endosome membrane]
(Homo sapiens)
Participates
as an input of
C-ter TLR7 dimer binds HCQ (Homo sapiens)
RSV ssRNA binds C-ter TLR7 dimer (Homo sapiens)
C-ter TLR7 dimer binds TLR7, TLR8 ligands (Homo sapiens)
C-ter TLR7 dimer binds imiquimod (Homo sapiens)
C-ter TLR7 dimer binds SARS-CoV-2 GU-rich ssRNA (Homo sapiens)
as a component of
C-ter TLR7 dimer: RSV ssRNA [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:imiquimod [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] (Homo sapiens)
C-ter TLR7 dimer:HCQ [endosome membrane] (Homo sapiens)
TLR7 dimer:SARS-CoV-2 ssRNA [endosome membrane] (Homo sapiens)
Inferred To
C-ter TLR7 dimer [endosome membrane]
(Bos taurus)
C-ter TLR7 dimer [endosome membrane]
(Canis familiaris)
C-ter TLR7 dimer [endosome membrane]
(Gallus gallus)
C-ter TLR7 dimer [endosome membrane]
(Mus musculus)
C-ter TLR7 dimer [endosome membrane]
(Rattus norvegicus)
C-ter TLR7 dimer [endosome membrane]
(Sus scrofa)
C-ter TLR7 dimer [endosome membrane]
(Xenopus tropicalis)
© 2025
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