Reactome | CTSK [endolysosome lumen]

CTSK [endolysosome lumen]

Stable Identifier

R-HSA-1678985

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endolysosome lumen

Synonyms

Cathepsin K, CATK_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Trafficking and processing of endosomal TLR (Homo sapiens)
      - TLR processing at low pH (Homo sapiens)
        
        Legumain/Cathepsins [endolysosome lumen] (Homo sapiens)
        
        Cathepsins B, K, L, S [endolysosome lumen] (Homo sapiens)
        
        CTSK [endolysosome lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P43235 CTSK

Gene Names

CTSK, CTSO, CTSO2

Chain

signal peptide:1-15, propeptide:16-114, chain:115-329

Reference Genes

BioGPS Gene:1513 CTSK

COSMIC (genes):CTSK CTSK

COSMIC (genes):CTSO CTSO

CTD Gene:1513 CTSK

dbSNP Gene:1513 CTSK

ENSEMBL:ENSG00000143387 CTSK

HGNC:2536 CTSK

KEGG:hsa:1513 CTSK

Monarch:1513 CTSK

NCBI Gene:1513 CTSK

OMIM:601105 CTSK

UCSC:P43235 CTSK

Reference Transcript

RefSeq:NM_000396.3 CTSK

Other Identifiers

11715496_a_at

128_at

129_g_at

1513

16692846

202450_PM_s_at

202450_s_at

2434610

2434611

2434612

2434614

2434615

2434617

2434618

2434619

2434620

2434621

2434622

2434623

2434624

2434625

2434626

2434627

2434628

2434630

2434631

2434632

38466_at

7919815

A_23_P34744

GE58942

GE80208

GE85811

GO:0000423

GO:0001957

GO:0001968

GO:0002376

GO:0003824

GO:0004197

GO:0004252

GO:0005515

GO:0005518

GO:0005576

GO:0005615

GO:0005654

GO:0005764

GO:0005773

GO:0005886

GO:0006508

GO:0006575

GO:0006590

GO:0006914

GO:0006915

GO:0006955

GO:0007005

GO:0008234

GO:0008656

GO:0009897

GO:0012501

GO:0014070

GO:0016020

GO:0016324

GO:0016787

GO:0022617

GO:0030154

GO:0030198

GO:0030574

GO:0032868

GO:0034224

GO:0036021

GO:0043202

GO:0043226

GO:0043231

GO:0043394

GO:0045453

GO:0045471

GO:0051603

GO:0061037

GO:0071356

GO:0071560

GO:0098772

GO:0140096

GO:1903131

GO:2001235

HMNXSV003041133

ILMN_1758895

PH_hs_0004783

TC01003211.hg

X82153_at

g4503150_3p_a_at

Participates

as a member of

Cathepsins B, K, L, S [endolysosome lumen] (Homo sapiens)

Other forms of this molecule

CTSK [extracellular region]

CTSK [lysosomal lumen]

Inferred To

Ctsk [endolysosome lumen] (Mus musculus)

Ctsk [endolysosome lumen] (Rattus norvegicus)

CTSK [endolysosome lumen] (Bos taurus)

CTSK [endolysosome lumen] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2350

OpenTargets

ENSG00000143387

ENSEMBL

ENSG00000143387, ENST00000676824, ENST00000676966, ENSP00000271651, ENST00000271651, ENSP00000504176, ENSP00000503723

ZINC - FDA approved

CATK_HUMAN

ZINC - Substances

CATK_HUMAN

ZINC - Biogenic

CATK_HUMAN

ZINC target

P43235

PRO

P43235

GlyGen

P43235

PDB

4DMX, 1AU0, 8C3D, 2R6N, 1YK8, 5J94, 5TUN, 2ATO, 6QL8, 6ASH, 1VSN, 6QM0, 3C9E, 1MEM, 1BY8, 6PXF, 4X6J, 4X6I, 7QBM, 7QBO, 1NLJ, 1AYW, 1AYU, 7QBN, 7PCK, 1ATK, 3KWZ, 1BGO, 6QLW, 2AUZ, 1AU3, 1U9V, 1U9X, 4N8W, 7NXM, 3O1G, 1YT7, 4DMY, 1AU2, 5JA7, 1Q6K, 5TDI, 1YK7, 4YV8, 5Z5O, 4YVA, 5JH3, 1NL6, 6QLM, 6QBS, 3OVZ, 4X6H, 4N79, 3KWB, 1SNK, 1AYV, 6HGY, 7QBL, 3KX1, 3O0U, 3H7D, 2BDL, 2AUX, 6QLX, 3KW9, 7NXL, 1AU4, 1TU6, 1U9W

ZINC - Investigational

CATK_HUMAN

ZINC - Metabolites

CATK_HUMAN

IntEnz

3.4.22.38

HPA

ENSG00000143387-CTSK

GeneCards

CTSK

Pharos - Targets

P43235

Orphanet

CTSK

ZINC - Predictions - Purchasable

CATK_HUMAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07711 CTSL	8	CTSL(292-333) [endocytic vesicle lumen] (R-HSA-9686680) CTSL(114-288) [endocytic vesicle lumen] (R-HSA-9686686) CTSL(114-288) [endolysosome lumen] (R-HSA-1679050) CTSL(292-333) [endolysosome lumen] (R-HSA-1679026) CTSL1(114-288) [early endosome lumen] (R-HSA-4127474) CTSL1(114-288) [lysosomal lumen] (R-HSA-1181225) CTSL(292-333) [extracellular region] (R-HSA-449863) CTSL(114-288) [extracellular region] (R-HSA-449861)	0.527	3
UniProt:O60911 CTSV	4	CTSL2 [endolysosome lumen] (R-HSA-4127477) CTSL2 [extracellular region] (R-HSA-2228669) CTSL2 [early endosome lumen] (R-HSA-4127471) CTSL2 [lysosomal lumen] (R-HSA-1181232)	0.527	2