Reactome | TLR8 [endoplasmic reticulum membrane]

TLR8 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-1678947

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

FL-TLR8, Toll Like Receptor 8 (TLR 8)

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External Reference Information

External Reference

UniProt:Q9NR97 TLR8

Gene Names

TLR8, UNQ249/PRO286

Chain

signal peptide:1-26, chain:27-1041

Reference Genes

BioGPS Gene:51311 TLR8

COSMIC (genes):TLR8 TLR8

CTD Gene:51311 TLR8

dbSNP Gene:51311 TLR8

ENSEMBL:ENSG00000101916 TLR8

HGNC:15632 TLR8

KEGG:hsa:51311 TLR8

Monarch:51311 TLR8

NCBI Gene:51311 TLR8

OMIM:300366 TLR8

UCSC:Q9NR97 TLR8

Reference Transcript

Other Identifiers

11726947_a_at

11726948_at

17101537

220832_PM_at

220832_at

229560_PM_at

229560_at

3969119

3969121

3969122

3969123

3969124

3969125

3969126

3969127

3969128

51311

54495_at

8166065

A_14_P137084

A_23_P73837

GE531921

GO:0000139

GO:0001932

GO:0002224

GO:0002376

GO:0003677

GO:0003723

GO:0003725

GO:0003727

GO:0005515

GO:0005768

GO:0005789

GO:0005886

GO:0006954

GO:0007165

GO:0007249

GO:0009615

GO:0009897

GO:0010008

GO:0016020

GO:0016064

GO:0031410

GO:0032695

GO:0032727

GO:0032728

GO:0032729

GO:0032731

GO:0032755

GO:0032757

GO:0034158

GO:0036020

GO:0038023

GO:0038187

GO:0042802

GO:0043123

GO:0043226

GO:0045087

GO:0045089

GO:0051607

GO:0060089

GO:0060255

GO:0071260

GO:0098542

HMNXSV003017219

Hs.62699.0.A1_3p_at

ILMN_1657892

ILMN_1682251

ILMN_1705047

PH_hs_0014076

TC0X000052.hg

g7706147_3p_at

Participates

as a candidate of

TLR7/8/9 [endoplasmic reticulum membrane] (Homo sapiens)

as a component of

FL-TLR8 dimer [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

TLR8 [endosome membrane]

TLR8 [Golgi membrane]

TLR8 [endolysosome membrane]

Inferred To

tlr8 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Tlr8 [endoplasmic reticulum membrane] (Mus musculus)

Tlr8 [endoplasmic reticulum membrane] (Rattus norvegicus)

TLR8 [endoplasmic reticulum membrane] (Canis familiaris)

TLR8 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_619542.1, XP_011543832.1, XP_011543831.1, NP_057694.2

Guide to Pharmacology - Targets

1758

OpenTargets

ENSG00000101916

ENSEMBL

ENSP00000218032, ENSP00000312082, ENST00000311912, ENST00000218032

ZINC - Substances

TLR8_HUMAN

ZINC target

Q9NR97

PRO

Q9NR97

GlyGen

Q9NR97

PDB

6KYA, 6V9U, 4R09, 3W3K, 5HDH, 5AWA, 3W3L, 5AWB, 4R0A, 6ZJZ, 6WML, 4R07, 4QC0, 4QBZ, 3W3J, 4R08, 4R6A, 3W3G, 5WYZ, 5AWD, 5AWC, 3WN4, 5Z14, 7CRF, 5Z15, 5WYX, 8PFI, 6TY5, 7R53, 7R54, 7R52, 7RC9, 3W3M, 5AZ5, 3W3N, 7YTX

ZINC - Investigational

TLR8_HUMAN

HPA

ENSG00000101916-TLR8

Pharos - Targets

Q9NR97

ZINC - Predictions - Purchasable

TLR8_HUMAN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.602	4