Reactome | CNPY3 [endoplasmic reticulum lumen]

CNPY3 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-1678932

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Locations in the PathwayBrowser for interactor UniProt:O00501 CLDN5

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External Reference Information

External Reference

UniProt:Q9BT09 CNPY3

Gene Names

CNPY3, CTG4A, ERDA5, PRAT4A, TNRC5, HSPC084, UNQ1934/PRO4409

Chain

signal peptide:1-30, chain:31-278

Reference Genes

BioGPS Gene:10695 CNPY3

COSMIC (genes):CNPY3 CNPY3

CTD Gene:10695 CNPY3

dbSNP Gene:10695 CNPY3

ENSEMBL:ENSG00000137161 CNPY3

HGNC:11968 CNPY3

KEGG:hsa:10695 CNPY3

Monarch:10695 CNPY3

NCBI Gene:10695 CNPY3

OMIM:610774 CNPY3

UCSC:Q9BT09 CNPY3

Reference Transcript

RefSeq:NM_006586.4 CNPY3

Other Identifiers

10695

11739118_a_at

11739119_s_at

11754976_x_at

1552977_PM_a_at

1552977_a_at

17008706

217931_PM_at

217931_at

2907461

2907462

2907463

2907468

2907474

2907483

2907484

2907487

2907488

2907489

2907490

2907491

2907492

39280_at

45819_at

8119609

A_23_P19352

A_24_P277747

GE61549

GO:0002376

GO:0005102

GO:0005515

GO:0005783

GO:0005788

GO:0043226

GO:0045087

GO:0098542

HMNXSV003045293

HMNXSV003050199

Hs2.56828.1.S1_3p_s_at

ILMN_1669674

ILMN_1812967

PH_hs_0024966

TC06000588.hg

TC06002794.hg

g13325207_3p_at

g13325207_3p_x_at

Participates

as an input of

TLR folding by chaperones GP96 and CNPY3 (Homo sapiens)

as an output of

Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex (Homo sapiens)

as a component of

ATP-bound Gp96 dimer:CNPY3:TLR7/8/9 [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

CNPY3 [endoplasmic reticulum lumen] (Bos taurus)

CNPY3 [endoplasmic reticulum lumen] (Canis familiaris)

CNPY3 [endoplasmic reticulum lumen] (Gallus gallus)

CNPY3 [endoplasmic reticulum lumen] (Sus scrofa)

Cnpy3 [endoplasmic reticulum lumen] (Mus musculus)

Cnpy3 [endoplasmic reticulum lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_006577.2

OpenTargets

ENSG00000137161

ENSEMBL

ENSP00000361926, ENST00000372836

HPA

ENSG00000137161-CNPY3

PRO

Q9BT09

Pharos - Targets

Q9BT09

GlyGen

Q9BT09

Orphanet

CNPY3

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IW52 SLITRK4	1	SLITRK4 [plasma membrane] (R-HSA-6797855)	0.589	2
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:O00501 CLDN5	2	CLDN5 [cell junction] (R-HSA-421264) CLDN5 [plasma membrane] (R-HSA-419991)	0.556	3
UniProt:P48051 KCNJ6	1	KCNJ6 [plasma membrane] (R-HSA-975242)	0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P20774 OGN	11	N-glycan OGN [Golgi lumen] (R-HSA-2046182) Gal-glycan OGN [Golgi lumen] (R-HSA-2046218) Keratan(1)-OGN [Golgi lumen] (R-HSA-2046289) Keratan(2)-OGN [Golgi lumen] (R-HSA-2046152) Keratan(3)-OGN [Golgi lumen] (R-HSA-2046211) Keratan(4)-OGN [Golgi lumen] (R-HSA-2046142) KS(2)-OGN [Golgi lumen] (R-HSA-2046300) KS(1)-OGN [Golgi lumen] (R-HSA-2046262) KS(2)-OGN [extracellular region] (R-HSA-2046275) OGN [lysosomal lumen] (R-HSA-2105000) KS(2)-OGN [lysosomal lumen] (R-HSA-2046243)	0.527	3
UniProt:Q9HCJ2 LRC4C			0.527	2
UniProt:O43300 LRRTM2	1	LRRTM2 [plasma membrane] (R-HSA-6797966)	0.527	2
UniProt:Q9BTT6 LRRC1	1	LRRC1 [cytosol] (R-HSA-9715190)	0.527	3
UniProt:Q9GZU5 NYX			0.527	2
UniProt:O60602 TLR5	1	TLR5 [plasma membrane] (R-HSA-168013)	0.527	2
UniProt:P59665 DEFA1	9	DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(65-94) [extracellular region] (R-HSA-1462022) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053)	0.527	2
UniProt:Q96JA1 LRIG1	2	Ub-LRIG1 [plasma membrane] (R-HSA-8875434) LRIG1 [plasma membrane] (R-HSA-197745)	0.527	3
UniProt:Q92626 PXDN	1	PXDN [extracellular region] (R-HSA-2559628)	0.527	2
UniProt:O14498 ISLR	2	ISLR [extracellular region] (R-HSA-8848919) ISLR [platelet alpha granule lumen] (R-HSA-8848912)	0.527	3
UniProt:Q6EMK4 VASN			0.527	2
UniProt:P62341 SELT			0.527	2
UniProt:Q7L985 LIGO2			0.527	3
UniProt:Q86UE6 LRRTM1	1	LRRTM1 [plasma membrane] (R-HSA-6797964)	0.527	2
UniProt:Q9H9A6 LRC40			0.527	2
UniProt:Q8IYK4 COLGALT2	1	COLGALT2 [endoplasmic reticulum lumen] (R-HSA-1981122)	0.527	2
UniProt:Q86YC3 LRC33			0.527	2

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