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EIF4E2 [cytosol]
Stable Identifier
R-HSA-1678822
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
4EHP, Eukaryotic translation initiation factor 4E type 2, IF4E2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q99814%20EPAS1
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
ISGylation of protein translation regulator 4EHP (Homo sapiens)
EIF4E2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60573 EIF4E2
Gene Names
EIF4E2, EIF4EL3
Chain
chain:1-245
Reference Genes
BioGPS Gene:9470 EIF4E2
COSMIC (genes):EIF4E2 EIF4E2
CTD Gene:9470 EIF4E2
dbSNP Gene:9470 EIF4E2
ENSEMBL:ENSG00000135930 EIF4E2
ENSEMBL_homo_sapiens_GENE:ENSG00000135930.15 EIF4E2
HGNC:3293 EIF4E2
KEGG Gene (Homo sapiens):9470 EIF4E2
Monarch:9470 EIF4E2
NCBI Gene:9470 EIF4E2
OMIM:605895 EIF4E2
UCSC:O60573 EIF4E2
Reference Transcript
RefSeq:NM_001276336.1 EIF4E2
RefSeq:NM_004846.3 EIF4E2
Other Identifiers
11717831_a_at
11745933_a_at
209393_PM_s_at
209393_s_at
213571_PM_s_at
213571_s_at
226734_PM_at
226734_at
2532430
2532433
2532439
2532441
2532442
2532445
2532446
2532447
2532448
2532455
2532456
2532457
2532458
2532459
2532460
2532471
2532472
32229_at
63829_at
8049180
81929_at
91510_at
9470
A_19_P00316244
A_19_P00316245
A_19_P00801511
A_21_P0014711
A_23_P165722
A_24_P934755
A_33_P3308050
A_33_P3308055
GE54332
GE860876
GO:0000339
GO:0000340
GO:0000932
GO:0002376
GO:0003723
GO:0003743
GO:0005515
GO:0005737
GO:0005829
GO:0005845
GO:0006412
GO:0006413
GO:0006417
GO:0008135
GO:0016281
GO:0017148
GO:0023052
GO:0031047
GO:0031625
GO:0035278
GO:0043226
GO:0045182
GO:0045947
GO:0060339
GO:0072344
GO:0098542
HMNXSV003040540
HMNXSV003053278
Hs.306915.0.S1_3p_at
ILMN_1738326
PH_hs_0038777
TC02003889.hg
g3172338_3p_s_at
Participates
as a component of
ISGylated 4EHP [cytosol] (Homo sapiens)
as an input of
ISGylation of protein translation regulator 4EHP (Homo sapiens)
Inferred To
eIF4EHP [cytosol]
(Drosophila melanogaster)
ife-4 [cytosol]
(Caenorhabditis elegans)
zgc:110542 [cytosol]
(Danio rerio)
MGC89871 [cytosol]
(Xenopus tropicalis)
EIF4E2 [cytosol]
(Bos taurus)
EIF4E2 [cytosol]
(Dictyostelium discoideum)
EIF4E2 [cytosol]
(Gallus gallus)
EIF4E2 [cytosol]
(Mus musculus)
EIF4E2 [cytosol]
(Plasmodium falciparum)
EIF4E2 [cytosol]
(Sus scrofa)
Homologues of EIF4E2 [cytosol]
(Bos taurus)
Homologues of EIF4E2 [cytosol]
(Dictyostelium discoideum)
Homologues of EIF4E2 [cytosol]
(Plasmodium falciparum)
LOC611215 [cytosol]
(Canis familiaris)
Ghost homologue of EIF4E2 [cytosol]
(Rattus norvegicus)
eIF4e3 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_004837.1
,
NP_001263265.1
OpenTargets
ENSG00000135930
HPA
ENSG00000135930-EIF4E2
GeneCards
O60573
Ensembl
ENSG00000135930
,
ENSP00000258416
,
ENST00000258416
,
ENSP00000386996
,
ENST00000409098
PRO
O60573
Pharos - Targets
O60573
PDB
2JGC
,
5NVL
,
5NVM
,
5NVN
,
2JGB
,
5NVK
,
5XLN
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRA8 4ET
0.712
4
UniProt:P15173 MYOG
1
MYOG [nucleoplasm]
(R-HSA-445160)
0.666
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
4
UniProt:Q96C00 ZBTB9
0.666
4
UniProt:P0C6X7-PRO_0000037310 REP
0.643
3
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.643
3
UniProt:Q9H257 CARD9
3
CARD9 [cytosol]
(R-HSA-561194)
p-T231-CARD9 [plasma membrane]
(R-HSA-5607623)
CARD9 [plasma membrane]
(R-HSA-5607662)
0.556
3
UniProt:Q5T124 UBXN11
1
UBXN11 [cytosol]
(R-HSA-9696514)
0.556
3
UniProt:Q7Z6G3-2 NECAB2
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:Q8IX15-3 HOMEZ
0.556
3
UniProt:O75478 TADA2A
1
TADA2A [nucleoplasm]
(R-HSA-3662284)
0.556
3
UniProt:Q01850 CDR2
0.556
3
UniProt:O43597 SPRY2
8
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
SPRY2 [plasma membrane]
(R-HSA-182924)
SPRY2 [cytosol]
(R-HSA-182949)
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
0.556
3
UniProt:Q8TD10 MIPO1
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:Q96R06 SPAG5
0.556
3
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
UniProt:Cerebral CLONE
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q9Y2J4-4 AMOTL2
0.556
3
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.556
3
UniProt:Q7Z3S9 NT2NA
0.556
3
UniProt:A1A4E9 A1A4E9
0.556
3
UniProt:Q9BYV2 TRI54
0.556
3
UniProt:Q70EL1 UBP54
0.556
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:P60370 KRTAP10-5
1
KRTAP10-5 [cytosol]
(R-HSA-6810260)
0.556
3
UniProt:Q8NA61 CBY2
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:Q9UPY8 MARE3
0.556
3
UniProt:P08727 KRT19
1
KRT19 [cytosol]
(R-HSA-6809617)
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:Q9Y5V3 MAGED1
1
MAGED1 [cytosol]
(R-HSA-196002)
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q9GZV8 PRDM14
1
PRDM14 [nucleoplasm]
(R-HSA-1112608)
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:P0DTD1-PRO_0000449620 REP
0.527
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.527
2
UniProt:O75420 GGYF1
0.508
2
UniProt:Q99814 EPAS1 (HIF2A)
5
HN-EPAS1 [cytosol]
(R-HSA-1234112)
2xHP-EPAS1 [nucleoplasm]
(R-HSA-1234151)
2xHP-EPAS1 [cytosol]
(R-HSA-1234149)
EPAS1 [nucleoplasm]
(R-HSA-452560)
EPAS1 [cytosol]
(R-HSA-1234119)
0.499
2
UniProt:Q99750 MDFI
0.488
2
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