IDS hydrolyses Heparan sulfate chain(5)

Stable Identifier
R-HSA-1678650
Type
Reaction
Species
Homo sapiens
Compartment
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Iduronate 2sulfatase (IDS) hydrolyses 2-sulfate groups from Liduronate 2-sulfate units of heparan sulfate. Defects in IDS are the cause of mucopolysaccharidosis type II (MPSII, MIM:309900), also called Hunter syndrome (Wilson et al. 1990).

Literature References
PubMed ID Title Journal Year
2122463 Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA

Morris, CP, Bielicki, J, Occhiodoro, T, Hopwood, JJ, Anson, DS, Clements, PR, Wilson, PJ

Proc Natl Acad Sci U S A 1990
Participants
Participates
Catalyst Activity

iduronate-2-sulfatase activity of IDS dimer [lysosomal lumen]

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