IDS hydrolyses Heparan sulfate chain(5)

Stable Identifier
R-HSA-1678650
Type
Reaction
Species
Homo sapiens
Compartment
lysosomal lumen
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IDS hydrolyses Heparan sulfate chain(5)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Iduronate 2sulfatase (IDS) hydrolyses 2-sulfate groups from Liduronate 2-sulfate units of heparan sulfate. Defects in IDS are the cause of mucopolysaccharidosis type II (MPSII, MIM:309900), also called Hunter syndrome (Wilson et al. 1990).

Literature References
PubMed ID Title Journal Year
2122463 Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA

Morris, CP, Bielicki, J, Occhiodoro, T, Hopwood, JJ, Anson, DS, Clements, PR, Wilson, PJ

Proc Natl Acad Sci U S A 1990
Participants
Input
Output
Participates
as an event of
Catalyst Activity

iduronate-2-sulfatase activity of IDS dimer [lysosomal lumen]

Physical Entity
IDS dimer [lysosomal lumen] (Homo sapiens)
Activity
iduronate-2-sulfatase activity (GO:0004423)
Orthologous Events
IDS hydrolyses Heparan sulfate chain(5) (Bos taurus)
IDS hydrolyses Heparan sulfate chain(5) (Canis familiaris)
IDS hydrolyses Heparan sulfate chain(5) (Danio rerio)
IDS hydrolyses Heparan sulfate chain(5) (Drosophila melanogaster)
IDS hydrolyses Heparan sulfate chain(5) (Gallus gallus)
IDS hydrolyses Heparan sulfate chain(5) (Mus musculus)
IDS hydrolyses Heparan sulfate chain(5) (Rattus norvegicus)
IDS hydrolyses Heparan sulfate chain(5) (Sus scrofa)
IDS hydrolyses Heparan sulfate chain(5) (Xenopus tropicalis)
Authored
Jassal, B  (2011-10-19)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-10-19)
Cite Us!