The fatty acid cycling model

Stable Identifier
Homo sapiens
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The "fatty acid cycling" hypothesis proposes that protonated fatty acids flip-flop in the membrane and deliver a proton to the matrix side. UCP1 catalyses the return of the fatty acid anion to the cytosolic side of the membrane, resulting in net proton transport catalysed by the protein.

Literature References
PubMed ID Title Journal Year
10653472 Anion carriers in fatty acid-mediated physiological uncoupling

Skulachev, VP

J Bioenerg Biomembr 1999
9821950 The mechanism of proton transport mediated by mitochondrial uncoupling proteins

Garlid, KD, Jaburek, M, Jezek, P

FEBS Lett 1998
8576230 On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein

Garlid, KD, Orosz, DE, Modriansky, M, Vassanelli, S, Jezek, P

J Biol Chem 1996
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