The fatty acid cycling model

Stable Identifier
R-HSA-167826
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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The fatty acid cycling model
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The "fatty acid cycling" hypothesis proposes that protonated fatty acids flip-flop in the membrane and deliver a proton to the matrix side. UCP1 catalyses the return of the fatty acid anion to the cytosolic side of the membrane, resulting in net proton transport catalysed by the protein.

Literature References
PubMed ID Title Journal Year
9821950 The mechanism of proton transport mediated by mitochondrial uncoupling proteins

Garlid, KD, Jezek, P, Jaburek, M

FEBS Lett 1998
10653472 Anion carriers in fatty acid-mediated physiological uncoupling

Skulachev, VP

J Bioenerg Biomembr 1999
8576230 On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein

Garlid, KD, Jezek, P, Modriansky, M, Orosz, DE, Vassanelli, S

J Biol Chem 1996
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Event Information
Go Biological Process
proton transmembrane transport (1902600)
Orthologous Events
The fatty acid cycling model (Bos taurus)
The fatty acid cycling model (Caenorhabditis elegans)
The fatty acid cycling model (Canis familiaris)
The fatty acid cycling model (Danio rerio)
The fatty acid cycling model (Drosophila melanogaster)
The fatty acid cycling model (Gallus gallus)
The fatty acid cycling model (Mus musculus)
The fatty acid cycling model (Rattus norvegicus)
The fatty acid cycling model (Sus scrofa)
The fatty acid cycling model (Xenopus tropicalis)
Created
Jassal, B  (2005-11-09)
Esteves, TC  (2005-11-09)
Brand, MD  (2005-11-09)
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