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MAP3K5 [cytosol]
Stable Identifier
R-HSA-167709
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ASK1, Mitogen-activated protein kinase kinase kinase 5, MEKK5, MAPKKK5
Locations in the PathwayBrowser for interactor UniProt:P20042 EIF2S2
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1) (Homo sapiens)
MAP3K5 [cytosol] (Homo sapiens)
MAP3K5 phosphorylates MKK3 and MKK6 (Homo sapiens)
MAP3K5 [cytosol] (Homo sapiens)
ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)
MAP3K5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99683 MAP3K5
Gene Names
MAP3K5, ASK1, MAPKKK5, MEKK5
Chain
chain:1-1374
Reference Genes
BioGPS Gene:4217 MAP3K5
COSMIC (genes):MAP3K5 MAP3K5
CTD Gene:4217 MAP3K5
dbSNP Gene:4217 MAP3K5
ENSEMBL:ENSG00000197442 MAP3K5
ENSEMBL_homo_sapiens_GENE:ENSG00000197442.11 MAP3K5
HGNC:6857 MAP3K5
KEGG Gene (Homo sapiens):4217 MAP3K5
Monarch:4217 MAP3K5
NCBI Gene:4217 MAP3K5
OMIM:602448 MAP3K5
UCSC:Q99683 MAP3K5
Reference Transcript
RefSeq:NM_005923.3 MAP3K5
Other Identifiers
11725474_a_at
11750630_s_at
1327_s_at
17024079
203836_PM_s_at
203836_s_at
203837_PM_at
203837_at
2975870
2975871
2975872
2975873
2975875
2975877
2975878
2975883
2975891
2975893
2975895
2975896
2975899
2975900
2975901
2975903
2975904
2975905
2975906
2975907
2975913
2975916
2975918
2975921
2975923
2975924
2975929
2975930
2975936
2975937
2975938
2975939
2975940
2975946
2975957
2975958
2975959
2975960
2975961
2975962
2975963
2975964
4217
8129804
A_23_P134125
A_33_P3377130
GE59347
GO:0000165
GO:0000166
GO:0000287
GO:0001934
GO:0002376
GO:0002931
GO:0003824
GO:0004672
GO:0004674
GO:0004706
GO:0004709
GO:0005515
GO:0005524
GO:0005737
GO:0005783
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0007254
GO:0008631
GO:0009897
GO:0010666
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0019901
GO:0019903
GO:0019904
GO:0023052
GO:0030154
GO:0032991
GO:0034198
GO:0034976
GO:0036211
GO:0036480
GO:0038066
GO:0042802
GO:0042803
GO:0043065
GO:0043067
GO:0043226
GO:0043280
GO:0043410
GO:0043507
GO:0045087
GO:0045663
GO:0045860
GO:0045893
GO:0046330
GO:0046872
GO:0048856
GO:0050896
GO:0051402
GO:0051403
GO:0070059
GO:0070301
GO:0071356
GO:0072577
GO:0090398
GO:0097190
GO:0097300
GO:0098542
GO:0106310
GO:0140096
GO:1900745
GO:1902170
GO:1902911
GO:1904707
GO:1990604
HMNXSV003003209
HMNXSV003020852
ILMN_1726547
PH_hs_0009153
TC06002146.hg
U67156_at
g1805499_3p_a_at
g6031181_3p_at
Participates
as an output of
ROS oxidize thioredoxin and activate MAP3K5 (Homo sapiens)
as a component of
MAP3K5:TXN [cytosol] (Homo sapiens)
Inferred To
MAP3K5 [cytosol]
(Bos taurus)
MAP3K5 [cytosol]
(Caenorhabditis elegans)
MAP3K5 [cytosol]
(Canis familiaris)
MAP3K5 [cytosol]
(Drosophila melanogaster)
MAP3K5 [cytosol]
(Gallus gallus)
MAP3K5 [cytosol]
(Mus musculus)
MAP3K5 [cytosol]
(Rattus norvegicus)
MAP3K5 [cytosol]
(Saccharomyces cerevisiae)
MAP3K5 [cytosol]
(Schizosaccharomyces pombe)
MAP3K5 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_005914.1
ZINC - World Drugs
M3K5_HUMAN
Guide to Pharmacology - Targets
2080
OpenTargets
ENSG00000197442
ZINC - Substances
M3K5_HUMAN
ZINC target
Q99683
ZINC - Biogenic
M3K5_HUMAN
PRO
Q99683
PDB
5V19
,
5VIL
,
8QGY
,
5VIO
,
3VW6
,
6VRE
,
6E2M
,
4BIC
,
4BID
,
5UOR
,
6XIH
,
5UP3
,
6EJL
,
4BIE
,
5UOX
,
4BF2
,
6OYW
,
7MU7
,
4BIB
,
6E2O
,
5ULM
,
6E2N
,
2CLQ
,
4BHN
,
6OYT
,
5V24
IntEnz
2.7.11.25
GeneCards
Q99683
HPA
ENSG00000197442-MAP3K5
Ensembl
ENST00000359015
,
ENSP00000351908
,
ENSG00000197442
Pharos - Targets
Q99683
ZINC - Predictions - Purchasable
M3K5_HUMAN
HMDB Protein
HMDBP08751
Interactors (42)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.806
7
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.783
5
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.779
5
UniProt:P46734 MAP2K3
3
MAP2K3 [cytosol]
(R-HSA-168051)
p-S218,T222-MAP2K3 [cytosol]
(R-HSA-167955)
p-S218,T222-MAP2K3 [nucleoplasm]
(R-HSA-450229)
0.757
6
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.738
4
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.725
4
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.716
4
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.704
4
UniProt:P10599 TXN
4
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [cytosol]
(R-HSA-66000)
0.677
4
UniProt:Q969S3 ZN622
0.664
14
UniProt:Q99828 CIB1
0.66
7
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.659
3
UniProt:Q9D1C8 Vps28
1
Vps28 [endosome membrane]
(R-MMU-9631171)
0.602
5
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.558
2
UniProt:P50570-2 DNM2
0.556
3
UniProt:Q14114-3 Q141143
0.556
3
UniProt:P41091 EIF2S3
1
EIF2S3 [cytosol]
(R-HSA-72514)
0.556
3
UniProt:P20042 EIF2S2
1
EIF2S2 [cytosol]
(R-HSA-72512)
0.556
3
UniProt:Q8TB36 GDAP1
2
GDAP1 [peroxisomal membrane]
(R-HSA-9603788)
GDAP1 [cytosol]
(R-HSA-9603796)
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:P54652 HSPA2
2
HSPA2 [cytosol]
(R-HSA-3371408)
HSPA2 [nucleoplasm]
(R-HSA-912480)
0.556
3
UniProt:Q14204 DYNC1H1
3
DYNC1H1 [extracellular region]
(R-HSA-6806223)
DYNC1H1 [azurophil granule lumen]
(R-HSA-6799155)
DYNC1H1 [cytosol]
(R-HSA-380285)
0.556
3
UniProt:Q0VDC6 Q0VDC6
0.556
3
UniProt:P60891 PRPS1
1
PRPS1 [cytosol]
(R-HSA-73483)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:P02489 CRYAA
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.556
3
UniProt:Q92876 KLK6
0.556
3
UniProt:O43464 HTRA2
1
HTRA2 [mitochondrial intermembrane space]
(R-HSA-56655)
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q9UBQ0-2 VPS29
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:O95382 M3K6
0.547
2
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.544
3
UniProt:P04324 NEF
0.544
2
UniProt:P25445 FAS
1
FAS [plasma membrane]
(R-HSA-66248)
0.536
2
UniProt:Q9Y275 TNFSF13B
1
sBAFF [extracellular region]
(R-HSA-5676541)
0.527
2
UniProt:Q16637 SMN1
2
SMN1 [nucleoplasm]
(R-HSA-191892)
SMN1 [cytosol]
(R-HSA-191839)
0.524
3
UniProt:Q9WTR2 M3K6
0.508
3
UniProt:Q5VWQ8 DAB2IP
1
DAB2IP [cytosol]
(R-HSA-5658238)
0.508
2
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.483
2
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