Reactome | AP1S3 [cytosol]

AP1S3 [cytosol]

Stable Identifier

R-HSA-167692

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AP-1 sigma 1C

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - HIV Infection (Homo sapiens)
    - Host Interactions of HIV factors (Homo sapiens)
      - The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
        
        Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
        
        Nef mediated downregulation of MHC class I complex cell surface expression (Homo sapiens)
        
        Degradation of MHC I Complex (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 sigma [cytosol] (Homo sapiens)
        
        AP1S3 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 sigma [cytosol] (Homo sapiens)
        
        AP1S3 [cytosol] (Homo sapiens)
        
        Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 sigma [cytosol] (Homo sapiens)
        
        AP1S3 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 sigma [cytosol] (Homo sapiens)
        
        AP1S3 [cytosol] (Homo sapiens)
        
        Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
        
        Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 sigma [cytosol] (Homo sapiens)
        
        AP1S3 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 sigma [cytosol] (Homo sapiens)
        
        AP1S3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96PC3 AP1S3

Gene Names

AP1S3

Chain

chain:1-154

Reference Genes

BioGPS Gene:130340 AP1S3

COSMIC (genes):AP1S3 AP1S3

CTD Gene:130340 AP1S3

dbSNP Gene:130340 AP1S3

ENSEMBL:ENSG00000152056.17 AP1S3

HGNC:18971 AP1S3

KEGG Gene (Homo sapiens):130340 AP1S3

Monarch:130340 AP1S3

NCBI Gene:130340 AP1S3

OMIM:615781 AP1S3

UCSC:Q96PC3 AP1S3

Reference Transcript

RefSeq:NM_001039569.1 AP1S3

Other Identifiers

11732496_a_at

11753670_a_at

11761673_at

130340

1555731_PM_a_at

1555731_a_at

1555733_PM_s_at

1555733_s_at

1555734_PM_x_at

1555734_x_at

16908985

237159_PM_x_at

237159_x_at

2601296

2601297

2601298

2601299

2601300

2601301

2601302

2601303

2601304

2601305

2601306

2601308

2601309

2601310

2601313

2601314

2601316

2601321

2601322

67062_r_at

68310_at

8059350

A_23_P385295

A_24_P105747

A_33_P3275707

A_33_P3288995

A_33_P3289005

GE88097

GO:0000139

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005794

GO:0005829

GO:0005886

GO:0005905

GO:0006605

GO:0006886

GO:0008150

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030121

GO:0030659

GO:0030674

GO:0031410

GO:0032588

GO:0032991

GO:0035615

GO:0043226

GO:0043231

GO:0060155

GO:1903232

HMNXSV003052107

Hs2.348666.3.S1_3p_a_at

Hs2.348666.3.S1_3p_x_at

ILMN_1768610

PH_hs_0024431

TC02002819.hg

Participates

as a member of

AP-1 sigma [cytosol] (Homo sapiens)

Other forms of this molecule

AP1S3 [cytoplasmic vesicle membrane]

AP1S3 [Golgi membrane]

AP1S3 [lysosomal membrane]

AP1S3 [trans-Golgi network membrane]

Inferred To

Ap1s3 [cytosol] (Mus musculus)

Ap1s3 [cytosol] (Rattus norvegicus)

Homologues of AP1S3 [cytosol] (Dictyostelium discoideum)

aps-1 [cytosol] (Caenorhabditis elegans)

AP-1sigma [cytosol] (Drosophila melanogaster)

ap1s3 [cytosol] (Xenopus tropicalis)

AP1S3 [cytosol] (Bos taurus)

AP1S3 [cytosol] (Danio rerio)

AP1S3 [cytosol] (Gallus gallus)

AP1S3 [cytosol] (Plasmodium falciparum)

AP1S3 [cytosol] (Sus scrofa)

ap1s1 [cytosol] (Dictyostelium discoideum)

vas2 [cytosol] (Schizosaccharomyces pombe)

APS1 [cytosol] (Saccharomyces cerevisiae)

ap1s2 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001034658.1

OpenTargets

ENSG00000152056

GeneCards

Q96PC3

HPA

ENSG00000152056-AP1S3

Ensembl

ENST00000443700, ENSG00000152056, ENST00000415298, ENST00000446015, ENSP00000379891, ENST00000396654, ENSP00000401705, ENSP00000397155, ENSP00000388738

PRO

Q96PC3

Pharos - Targets

Q96PC3

Orphanet

22886

PDB

6D83, 6CM9, 6CRI, 4HMY, 6D84, 6DFF