Reactome | AP1S3 [cytosol]

AP1S3 [cytosol]

Stable Identifier

R-HSA-167692

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AP-1 sigma 1C

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - HIV Infection (Homo sapiens)
    - Host Interactions of HIV factors (Homo sapiens)
      - The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
        
        Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
        
        Nef mediated downregulation of MHC class I complex cell surface expression (Homo sapiens)
        
        Degradation of MHC I Complex (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 sigma [cytosol] (Homo sapiens)
        
        AP1S3 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 sigma [cytosol] (Homo sapiens)
        
        AP1S3 [cytosol] (Homo sapiens)
        
        Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 sigma [cytosol] (Homo sapiens)
        
        AP1S3 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 sigma [cytosol] (Homo sapiens)
        
        AP1S3 [cytosol] (Homo sapiens)
        
        Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
        
        Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 sigma [cytosol] (Homo sapiens)
        
        AP1S3 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 sigma [cytosol] (Homo sapiens)
        
        AP1S3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96PC3 AP1S3

Gene Names

AP1S3

Chain

chain:1-154

Reference Genes

BioGPS Gene:130340 AP1S3

COSMIC (genes):AP1S3 AP1S3

CTD Gene:130340 AP1S3

dbSNP Gene:130340 AP1S3

ENSEMBL:ENSG00000152056 AP1S3

HGNC:18971 AP1S3

KEGG Gene (Homo sapiens):130340 AP1S3

Monarch:130340 AP1S3

NCBI Gene:130340 AP1S3

OMIM:615781 AP1S3

UCSC:Q96PC3 AP1S3

Reference Transcript

RefSeq:NM_001039569.1 AP1S3

Other Identifiers

11732496_a_at

11753670_a_at

11761673_at

130340

1555731_a_at

1555733_s_at

1555734_x_at

16908985

237159_x_at

2601296

2601297

2601298

2601299

2601300

2601301

2601302

2601303

2601304

2601305

2601306

2601308

2601309

2601310

2601313

2601314

2601316

2601321

2601322

4HMY

66782

67062_r_at

68310_at

6CM9

6CRI

6D83

6D84

6DFF

8059350

A_23_P385295

A_24_P105747

A_33_P3275707

A_33_P3288995

A_33_P3289005

AAH09606

AAH21898

AAL09586

AC012512

AC093884

AF393369

AK299026

AP1S3

AP1S3-203

AP1S3-205

AP1S3-206

AP1S3-208

B8ZZZ1

BAG61103

BC009606

BC021898

C9JZK4

CCDS42827

ENSG00000152056

ENSP00000379891

ENSP00000388738

ENSP00000397155

ENSP00000401705

ENST00000396654

ENST00000396654.6

ENST00000415298

ENST00000415298.5

ENST00000443700

ENST00000443700.5

ENST00000446015

ENST00000446015.6

EntrezGene:130340

EntrezGene:AP1S3

F8W8K9

G5E966

GE88097

GO:0000139

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005794

GO:0005829

GO:0005905

GO:0006605

GO:0006810

GO:0006886

GO:0008150

GO:0015031

GO:0016020

GO:0016192

GO:0019886

GO:0030117

GO:0030659

GO:0031410

GO:0032588

GO:0032991

GO:0043226

GO:0043231

GO:0044403

GO:0050690

HGNC:18971

HPA066782

Hs2.348666.3.S1_3p_a_at

Hs2.348666.3.S1_3p_x_at

ILMN_1768610

IPR000804

IPR011012

IPR016635

IPR022775

MIM:615781

MIM:616106

NM_001039569

NP_001034658

NR_110905

PF01217

PH_hs_0024431

TC02002819.hg

UPI0000124FED

UPI0000169EE5

UPI0000169FC0

UPI00003D357B

XM_011510600

XP_011508902

Participant Of

hasMember

AP-1 sigma [cytosol]

Other forms of this molecule

AP1S3 [cytoplasmic vesicle membrane]

AP1S3 [Golgi membrane]

AP1S3 [lysosomal membrane]

AP1S3 [trans-Golgi network membrane]

Inferred To

AP1S3 [cytosol] (Bos taurus)

AP1S3 [cytosol] (Caenorhabditis elegans)

AP1S3 [cytosol] (Canis familiaris)

AP1S3 [cytosol] (Danio rerio)

AP1S3 [cytosol] (Dictyostelium discoideum)

AP1S3 [cytosol] (Drosophila melanogaster)

AP1S3 [cytosol] (Gallus gallus)

AP1S3 [cytosol] (Mus musculus)

AP1S3 [cytosol] (Plasmodium falciparum)

AP1S3 [cytosol] (Rattus norvegicus)

AP1S3 [cytosol] (Saccharomyces cerevisiae)

AP1S3 [cytosol] (Schizosaccharomyces pombe)

AP1S3 [cytosol] (Sus scrofa)

AP1S3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001034658.1

OpenTargets

ENSG00000152056

GeneCards

Q96PC3

PRO

Q96PC3

Orphanet

22886

PDB

6D83, 4HMY, 6D84, 6CM9, 6CRI, 6DFF