TrkA phosphorylates PLCG1

Stable Identifier
R-HSA-167683
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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TrkA phosphorylates PLCG1
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Mutational analysis of tyrosine residues, highly conserved in the cytoplasmic domain of all Trk receptors, reveal that the activation of PLC-gamma is necessary to mobilize Ca2+ from intracellular stores, the key mechanism for regulated NT secretion.
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Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of Active TrkA receptor:PLCG1 complex [plasma membrane]

Physical Entity
Active TrkA receptor:PLCG1 complex [plasma membrane] (Homo sapiens)
Activity
transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Inferred From
Active Trk phosphorylates Plcg1 (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2005-11-01)
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