TrkA phosphorylates PLCG1

Stable Identifier
R-HSA-167683
Type
Reaction
Species
Homo sapiens
Compartment
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Mutational analysis of tyrosine residues, highly conserved in the cytoplasmic domain of all Trk receptors, reveal that the activation of PLC-gamma is necessary to mobilize Ca2+ from intracellular stores, the key mechanism for regulated NT secretion.

Participants
Participates
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of Active TrkA receptor:PLCG1 complex [plasma membrane]

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