Formation of Nef CD28 cytoplasmic tail complex

Stable Identifier
R-HSA-167630
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Formation of Nef CD28 cytoplasmic tail complex
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Down-regulation of CD28 receptors involves a dileucine-based motif in the second disordered loop of Nef, which connects Nef to adaptor protein (AP) complex, which is a part of cellular endocytosis machinery.
Literature References
PubMed ID Title Journal Year
11285224 Mechanism for down-regulation of CD28 by Nef

Shohdy, N, Swigut, T, Skowronski, J

EMBO J 2001
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Gillespie, ME  (2007-07-25)
Reviewed
Skowronski, J  (2007-08-07)
Created
Gillespie, ME  (2005-10-21)
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