Reactome | PI4KB binds to ARF1/3:GTP at the Golgi membrane

PI4KB binds to ARF1/3:GTP at the Golgi membrane

Stable Identifier

R-HSA-1676152

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

5/5

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PI4KB binds to ARF1/3:GTP at the Golgi membrane

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At the Golgi membrane, ADP-ribosylation factor 1 and 3 (ARF1 and ARF3) complexed to GTP bind to phosphatidylinositol 4-kinase beta (PI4KB) and activate it (Haynes et al. 2007, Wong et al. 1997, Godi et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9148941	Subcellular locations of phosphatidylinositol 4-kinase isoforms Wong, K, Meyers, ddR, Cantley, LC	J Biol Chem	1997
10559940	ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex Godi, A, Pertile, P, Meyers, R, Marra, P, Di Tullio, G, Iurisci, C, Luini, A, Corda, D, De Matteis, MA	Nat Cell Biol	1999
17555535	Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta Haynes, LP, Sherwood, MW, Dolman, NJ, Burgoyne, RD	Traffic	2007