PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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At the plasma membrane, phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) 3-kinase catalytic subunits form complexes with regulatory subunits. These complexes along with phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunits alpha (PIK3C2A), beta (PIK3C2B), and gamma (PIK3C2G) phosphorylate phosphatidylinositol 4-phosphate (PI4P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). The PI(4,5)P2 3-kinase complexes involved are: PI(4,5)P2 3-kinase catalytic subunit alpha isoform (PIK3CA) bound to PI 3-kinase regulatory subunit alpha/beta/gamma (PIK3R1/2/3); beta (PIK3CB) bound to PIK3R1/2/3; delta (PIK3CD) bound to PIK3R1/2/3; and gamma (PIK3CG) bound to PI 3-kinase regulatory subunit 5 (PIK3R5) or 6 (PIK3R6).

The following lists the above proteins with their corresponding literature references: PIK3C2A (Arcaro et al. 2000); PIK3C2B (Arcaro et al. 2000, Arcaro et al. 1998); PIK3C2G (Misawa et al. 1998, Ono et al. 1998); PIK3CA:PIK3R1, PIK3CA:PIK3R2, PIK3CA:PIK3R3 (Vanhaesebroeck et al. 1997); PIK3CB:PIK3R1, PIK3CB:PIK3R2, PIK3CB:PIK3R3 (Meier et al. 2004, Guo et al. 1997); PIK3CD:PIK3R1, PIK3CD:PIK3R2, PIK3CD:PIK3R3 (Vanhaesebroeck et al. 1997); and PIK3CG:PIK3R5, PIK3CG:PIK3R6 (Suire et al. 2005, Stoyanov et al. 1995).

Literature References
PubMed ID Title Journal Year
9830063 Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity

Downward, J, Waterfield, MD, Arcaro, A, Ahmadi, K, Stein, R, Volinia, S, Layton, MJ, Watton, SJ, Zvelebil, MJ, Gout, I

J Biol Chem 1998
9286278 Phosphatidylinositol 3-kinase in bovine photoreceptor rod outer segments

Chen, H, Anderson, RE, Guo, X, Ghalayini, AJ

Invest Ophthalmol Vis Sci 1997
9113989 P110delta, a novel phosphoinositide 3-kinase in leukocytes

Downward, J, Higashi, K, Waterfield, MD, Volinia, S, Stein, R, Vanhaesebroeck, B, Warne, PH, Zvelebil, MJ, Kotani, K, Welham, MJ

Proc Natl Acad Sci U S A 1997
10805725 Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

Waterfield, MD, Arcaro, A, Wallasch, C, Ullrich, A, Zvelebil, MJ, Domin, J

Mol Cell Biol 2000
15135396 Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms

Lingaraj, T, Cook, JA, Meier, TI, Radding, JA, Smith, MC, Horn, C, Thomas, JE

Protein Expr Purif 2004
15797027 p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma

Stephens, L, Coadwell, J, Suire, S, Davidson, K, Ferguson, GJ, Hawkins, P

Curr Biol 2005
9514948 Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain

Copeland, NG, Yoshimura, A, Jenkins, NA, Gilbert, DJ, Ohtsubo, M, Misawa, H

Biochem Biophys Res Commun 1998
9516481 A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration

Nakagawa, T, Kondo, H, Suzuki, M, Sakagami, H, Saito, S, Ono, F, Matsuno, S, Goto, K, Owada, Y

J Biol Chem 1998
7624799 Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

Malek, D, Nurnberg, B, Dhand, R, Vanhaesebroeck, B, Volinia, S, Loubtchenkov, M, Stoyanov, B, Hanck, T, Stoyanova, S, Rubio, I

Science 1995
Catalyst Activity

1-phosphatidylinositol-4-phosphate 3-kinase activity of PIK3(2) [cytosol]

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