Reactome | PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane

PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane

Stable Identifier

R-HSA-1676109

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane

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At the plasma membrane, phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) 3-kinase catalytic subunits form complexes with regulatory subunits. These complexes along with phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunits alpha (PIK3C2A), beta (PIK3C2B), and gamma (PIK3C2G) phosphorylate phosphatidylinositol 4-phosphate (PI4P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). The PI(4,5)P2 3-kinase complexes involved are: PI(4,5)P2 3-kinase catalytic subunit alpha isoform (PIK3CA) bound to PI 3-kinase regulatory subunit alpha/beta/gamma (PIK3R1/2/3); beta (PIK3CB) bound to PIK3R1/2/3; delta (PIK3CD) bound to PIK3R1/2/3; and gamma (PIK3CG) bound to PI 3-kinase regulatory subunit 5 (PIK3R5) or 6 (PIK3R6).

The following lists the above proteins with their corresponding literature references: PIK3C2A (Arcaro et al. 2000); PIK3C2B (Arcaro et al. 2000, Arcaro et al. 1998); PIK3C2G (Misawa et al. 1998, Ono et al. 1998); PIK3CA:PIK3R1, PIK3CA:PIK3R2, PIK3CA:PIK3R3 (Vanhaesebroeck et al. 1997); PIK3CB:PIK3R1, PIK3CB:PIK3R2, PIK3CB:PIK3R3 (Meier et al. 2004, Guo et al. 1997); PIK3CD:PIK3R1, PIK3CD:PIK3R2, PIK3CD:PIK3R3 (Vanhaesebroeck et al. 1997); and PIK3CG:PIK3R5, PIK3CG:PIK3R6 (Suire et al. 2005, Stoyanov et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
9830063	Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity Arcaro, A, Volinia, S, Zvelebil, MJ, Stein, R, Watton, SJ, Layton, MJ, Gout, I, Ahmadi, K, Downward, J, Waterfield, MD	J Biol Chem	1998
9286278	Phosphatidylinositol 3-kinase in bovine photoreceptor rod outer segments Guo, X, Ghalayini, AJ, Chen, H, Anderson, RE	Invest Ophthalmol Vis Sci	1997
9113989	P110delta, a novel phosphoinositide 3-kinase in leukocytes Vanhaesebroeck, B, Welham, MJ, Kotani, K, Stein, R, Warne, PH, Zvelebil, MJ, Higashi, K, Volinia, S, Downward, J, Waterfield, MD	Proc Natl Acad Sci U S A	1997
10805725	Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors Arcaro, A, Zvelebil, MJ, Wallasch, C, Ullrich, A, Waterfield, MD, Domin, J	Mol Cell Biol	2000
15135396	Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms Meier, TI, Cook, JA, Thomas, JE, Radding, JA, Horn, C, Lingaraj, T, Smith, MC	Protein Expr Purif	2004
15797027	p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma Suire, S, Coadwell, J, Ferguson, GJ, Davidson, K, Hawkins, P, Stephens, L	Curr Biol	2005
9514948	Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain Misawa, H, Ohtsubo, M, Copeland, NG, Gilbert, DJ, Jenkins, NA, Yoshimura, A	Biochem Biophys Res Commun	1998
9516481	A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration Ono, F, Nakagawa, T, Saito, S, Owada, Y, Sakagami, H, Goto, K, Suzuki, M, Matsuno, S, Kondo, H	J Biol Chem	1998
7624799	Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase Stoyanov, B, Volinia, S, Hanck, T, Rubio, I, Loubtchenkov, M, Malek, D, Stoyanova, S, Vanhaesebroeck, B, Dhand, R, Nurnberg, B	Science	1995