PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane

Stable Identifier
R-HSA-1675974
Type
Reaction [transition]
Species
Homo sapiens
Compartment
early endosome membrane, cytosol
ReviewStatus
5/5
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PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
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At the early endosome membrane, phosphatidylinositol 4-kinase type 2-alpha/beta (PI4K2A/B) (Balla et al. 2002) phosphorylates phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).

Literature References
PubMed ID Title Journal Year
11923287 Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments

Balla, T, Tuymetova, G, Balla, A, Barshishat, M, Geiszt, M

J Biol Chem 2002
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Catalyst Activity

1-phosphatidylinositol 4-kinase activity of PI4K2A/2B [cytosol]

Physical Entity
PI4K2A/2B [cytosol] (Homo sapiens)
Activity
1-phosphatidylinositol 4-kinase activity (GO:0004430)
Orthologous Events
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Bos taurus)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Caenorhabditis elegans)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Canis familiaris)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Danio rerio)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Drosophila melanogaster)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Gallus gallus)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Mus musculus)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Rattus norvegicus)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Saccharomyces cerevisiae)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Schizosaccharomyces pombe)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Sus scrofa)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Xenopus tropicalis)
Cross References
Rhea
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
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