PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane

Stable Identifier
R-HSA-1675974
Type
Reaction [transition]
Species
Homo sapiens
Compartment
early endosome membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the early endosome membrane, phosphatidylinositol 4-kinase type 2-alpha/beta (PI4K2A/B) (Balla et al. 2002) phosphorylates phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).
Literature References
PubMed ID Title Journal Year
11923287 Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments

Balla, T, Tuymetova, G, Balla, A, Barshishat, M, Geiszt, M

J Biol Chem 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

1-phosphatidylinositol 4-kinase activity of PI4K2A/2B [cytosol]

Physical Entity
PI4K2A/2B [cytosol] (Homo sapiens)
Activity
1-phosphatidylinositol 4-kinase activity (GO:0004430)
Orthologous Events
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Bos taurus)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Caenorhabditis elegans)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Canis familiaris)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Danio rerio)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Drosophila melanogaster)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Gallus gallus)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Mus musculus)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Rattus norvegicus)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Saccharomyces cerevisiae)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Schizosaccharomyces pombe)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Sus scrofa)
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Xenopus tropicalis)
Cross References
Rhea
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
Cite Us!