PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane

Stable Identifier
R-HSA-1675928
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Reaction [transition]
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Homo sapiens
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At the Golgi membrane, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) (Domin et al. 2000, Arcaro et al. 2000) and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma (PIK3C2G) (Ono et al. 1998, Rozycka et al. 1998, Misawa et al. 1998) phosphorylate phosphatidylinositol 4-phosphate (PI4P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). PIK3C2G phosphorylates phosphatidylinositol (PI) and PI4P but not phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).

Literature References
PubMed ID Title Journal Year
10766823 The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles

Domin, J, Gaidarov, I, Smith, ME, Keen, JH, Waterfield, MD

J Biol Chem 2000
10805725 Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

Arcaro, A, Zvelebil, MJ, Wallasch, C, Ullrich, A, Waterfield, MD, Domin, J

Mol Cell Biol 2000
9878262 cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12

Rozycka, M, Lu, YJ, Brown, RA, Lau, MR, Shipley, JM, Fry, MJ

Genomics 1998
9516481 A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration

Ono, F, Nakagawa, T, Saito, S, Owada, Y, Sakagami, H, Goto, K, Suzuki, M, Matsuno, S, Kondo, H

J Biol Chem 1998
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Title
1-phosphatidylinositol-4-phosphate 3-kinase activity of PIK3C2A/G [cytosol]
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