At the Golgi membrane, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) (Domin et al. 2000, Arcaro et al. 2000) and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma (PIK3C2G) (Ono et al. 1998, Rozycka et al. 1998, Misawa et al. 1998) phosphorylate phosphatidylinositol 4-phosphate (PI4P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). PIK3C2G phosphorylates phosphatidylinositol (PI) and PI4P but not phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).
Waterfield, MD, Arcaro, A, Wallasch, C, Ullrich, A, Zvelebil, MJ, Domin, J
Waterfield, MD, Gaidarov, I, Domin, J, Smith, ME, Keen, JH
Rozycka, M, Fry, MJ, Lau, MR, Shipley, JM, Brown, RA, Lu, YJ
Nakagawa, T, Kondo, H, Suzuki, M, Sakagami, H, Saito, S, Ono, F, Matsuno, S, Goto, K, Owada, Y
1-phosphatidylinositol-4-phosphate 3-kinase activity of PIK3C2A/G [cytosol]
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