PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane

Stable Identifier
R-HSA-1675834
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In mice, phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) translocates from the plasma membrane to the early endosome membrane (Watt et al. 2004). A similar event has also been detected in cells from Chlorocebus sabaeus (Green Monkey) (Ivetac et al. 2005). In humans this event is inferred from the other two occurrences.

Literature References
PubMed ID Title Journal Year
14604433 Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy

Watt, SA, Kimber, WA, Fleming, IN, Leslie, NR, Downes, CP, Lucocq, JM

Biochem J 2004
15716355 The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane

Ivetac, I, Munday, AD, Kisseleva, MV, Zhang, XM, Luff, S, Tiganis, T, Whisstock, JC, Rowe, T, Majerus, PW, Mitchell, CA

Mol Biol Cell 2005
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