PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane

Stable Identifier
R-HSA-1675813
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Reaction
Species
Homo sapiens
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At the endoplasmic reticulum (ER) membrane, phosphatidylinositol 4-kinase alpha (PI4KA) (Wong et al. 1997, Gehrmann et al. 1999) or phosphatidylinositol 4-kinase type 2-beta (PI4K2B) (Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).

Literature References
PubMed ID Title Journal Year
12324459 Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP

Wei, YJ, Barylko, B, Yamamoto, M, Albanesi, JP, Wlodarski, P, Sun, HQ, Martínez, M, Yin, HL, Kunii, K

J Biol Chem 2002
9148941 Subcellular locations of phosphatidylinositol 4-kinase isoforms

Cantley, LC, Meyers, ddR, Wong, K

J Biol Chem 1997
10101268 Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230

Balla, A, Gülkan, H, Herberg, FW, Gehrmann, T, Mayr, GW, Vereb, G, Heilmeyer LM, Jr, Suer, S

Biochim Biophys Acta 1999
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Catalyst Activity

1-phosphatidylinositol 4-kinase activity of PI4KA/2B [cytosol]

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