PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane

Stable Identifier
R-HSA-1675813
Type
Reaction [transition]
Species
Homo sapiens
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At the endoplasmic reticulum (ER) membrane, phosphatidylinositol 4-kinase alpha (PI4KA) (Wong et al. 1997, Gehrmann et al. 1999) or phosphatidylinositol 4-kinase type 2-beta (PI4K2B) (Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).

Literature References
PubMed ID Title Journal Year
9148941 Subcellular locations of phosphatidylinositol 4-kinase isoforms

Wong, K, Meyers, ddR, Cantley, LC

J Biol Chem 1997
12324459 Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP

Wei, YJ, Sun, HQ, Yamamoto, M, Wlodarski, P, Kunii, K, Martínez, M, Barylko, B, Albanesi, JP, Yin, HL

J Biol Chem 2002
10101268 Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230

Gehrmann, T, Gülkan, H, Suer, S, Herberg, FW, Balla, A, Vereb, G, Mayr, GW, Heilmeyer LM, Jr

Biochim Biophys Acta 1999
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Catalyst Activity
Title
1-phosphatidylinositol 4-kinase activity of PI4KA/2B [cytosol]
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