PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane

Stable Identifier
R-HSA-1675780
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the plasma membrane, phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) (Balla et al. 2002, Minogue et al. 2001) and beta (PI4K2B) (Balla et al. 2002, Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P).
Literature References
PubMed ID Title Journal Year
11279162 Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family

Waugh, MG, Anderson, JS, Minogue, S, dos Santos, M, Cramer, R, Hsuan, JJ, Corless, S

J Biol Chem 2001
12324459 Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP

Wei, YJ, Barylko, B, Yamamoto, M, Albanesi, JP, Wlodarski, P, Sun, HQ, Martínez, M, Yin, HL, Kunii, K

J Biol Chem 2002
11923287 Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments

Balla, T, Tuymetova, G, Balla, A, Barshishat, M, Geiszt, M

J Biol Chem 2002
Participants
Participates
Catalyst Activity

1-phosphatidylinositol 4-kinase activity of PI4K2A/2B [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!