Reactome | PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane

PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane

Stable Identifier

R-HSA-1675776

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane

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At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A), beta (PIP4K2B) and gamma (PIP4K2C) homodimers and heterodimers (Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015) phosphorylate phosphatidylinositol 5-phosphate (PI5P) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).

The following lists the above proteins with their corresponding literature references: PIP4K2A (Rameh et al. 1997, Clarke et al. 2008, Clarke and Irvine 2013), PIP4K2B (Rameh et al. 1997, Clarke and Irvine 2013) and PIP4K2C (Clarke and Irvine 2013, Clarke et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
23758345	Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization Clarke, JH, Irvine, RF	Biochem. J.	2013
9367159	A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate Rameh, LE, Tolias, KF, Duckworth, BC, Cantley, LC	Nature	1997
19896968	Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases Clarke, JH, Wang, M, Irvine, RF	Adv Enzyme Regul	2010
25495341	The function of phosphatidylinositol 5-phosphate 4-kinase Î³ (PI5P4KÎ³) explored using a specific inhibitor that targets the PI5P-binding site Clarke, JH, Giudici, ML, Burke, JE, Williams, RL, Maloney, DJ, Marugan, J, Irvine, RF	Biochem. J.	2015
18753295	Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron Clarke, JH, Emson, PC, Irvine, RF	Am J Physiol Renal Physiol	2008