At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A), beta (PIP4K2B) and gamma (PIP4K2C) homodimers and heterodimers (Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015) phosphorylate phosphatidylinositol 5-phosphate (PI5P) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).The following lists the above proteins with their corresponding literature references: PIP4K2A (Rameh et al. 1997, Clarke et al. 2008, Clarke and Irvine 2013), PIP4K2B (Rameh et al. 1997, Clarke and Irvine 2013) and PIP4K2C (Clarke and Irvine 2013, Clarke et al. 2015).
Rameh, LE, Cantley, LC, Duckworth, BC, Tolias, KF
Irvine, RF, Clarke, JH
Wang, M, Irvine, RF, Clarke, JH
Irvine, RF, Clarke, JH, Burke, JE, Giudici, ML, Marugan, J, Maloney, DJ, Williams, RL
Irvine, RF, Emson, PC, Clarke, JH
1-phosphatidylinositol-5-phosphate 4-kinase activity of PIP4K2 dimers [cytosol]
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