SH2B binds JAK2

Stable Identifier
R-HSA-1675473
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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SH2B binds JAK2
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The SH2 domains of SH2B beta (Uniprot isoform Q9NRF2-2) binds JAK2 at Tyr813. SH2B beta is able to homodimerize while bound to JAK2 molecules, suggesting that SH2B binding and dimerization may help induce JAK2 transactivation (Nishi et al. 2005). Computational modeling suggests that SH2B beta can enhance Jak2 activation (Barua et al. 2009). The relevance of this for PRLR signalling has yet to be demonstrated.
Literature References
PubMed ID Title Journal Year
15767667 Kinase activation through dimerization by human SH2-B

Nishi, M, Werner, ED, Oh, BC, Frantz, JD, Dhe-Paganon, S, Hansen, L, Lee, J, Shoelson, SE

Mol Cell Biol 2005
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Orthologous Events
SH2B binds JAK2 (Bos taurus)
SH2B binds JAK2 (Canis familiaris)
SH2B binds JAK2 (Danio rerio)
SH2B binds JAK2 (Mus musculus)
SH2B binds JAK2 (Rattus norvegicus)
SH2B binds JAK2 (Sus scrofa)
Authored
Jupe, S  (2011-06-13)
Reviewed
Goffin, V  (2011-11-08)
Created
Jupe, S  (2011-10-17)
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