G-protein alpha subunit is inactivated

Stable Identifier
R-HSA-167415
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
ReviewStatus
5/5
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G-protein alpha subunit is inactivated
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Slow intrisinc GTPase activity results in an inactivation of the alpha-i subunit by hydrolyzing GTP to GDP.
Literature References
PubMed ID Title Journal Year
7937899 Mechanism of GTP hydrolysis by G-protein alpha subunits

Kleuss, C, Raw, AS, Lee, E, Sprang, SR, Gilman, AG

Proc Natl Acad Sci U S A 1994
8073283 Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

Coleman, DE, Berghuis, AM, Lee, E, Linder, ME, Gilman, AG, Sprang, SR

Science 1994
Participants
Input
Output
Participates
as an event of
Catalyst Activity

GTPase activity of G-protein alpha (q/11/14/15) [plasma membrane]

Physical Entity
G-protein alpha (q/11/14/15) [plasma membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
Orthologous Events
G-protein alpha subunit is inactivated (Bos taurus)
G-protein alpha subunit is inactivated (Caenorhabditis elegans)
G-protein alpha subunit is inactivated (Canis familiaris)
G-protein alpha subunit is inactivated (Danio rerio)
G-protein alpha subunit is inactivated (Dictyostelium discoideum)
G-protein alpha subunit is inactivated (Drosophila melanogaster)
G-protein alpha subunit is inactivated (Gallus gallus)
G-protein alpha subunit is inactivated (Mus musculus)
G-protein alpha subunit is inactivated (Rattus norvegicus)
G-protein alpha subunit is inactivated (Sus scrofa)
G-protein alpha subunit is inactivated (Xenopus tropicalis)
Authored
Le Novere, N  (2004-03-31)
Jassal, B  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Jassal, B  (2005-10-18)
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