TFIIS-mediated recovery of HIV-1 elongation from arrest

Stable Identifier
R-HSA-167288
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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TFIIS-mediated recovery of HIV-1 elongation from arrest
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TFIIS reactivates arrested RNA Pol II directly interacting with the enzyme resulting in endonucleolytic excision of nascent transcript ~7-14 nucleotides upstream of the 3' end. This reaction is catalyzed by the catalytic site and results in the generation of a new 3'-OH terminus that could be used for re-extension from the correctly base paired site (reviewed by Shilatifard et al., 2003).
Literature References
PubMed ID Title Journal Year
12676794 The RNA polymerase II elongation complex.

Conaway, JW, Shilatifard, A, Conaway, RC

Annu Rev Biochem 2003
Participants
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Output
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as an event of
Inferred From
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Matthews, L  (2005-07-27)
Rice, AP  (2005-07-27)
Created
Matthews, L  (2005-10-14)
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