This event was inferred from the corresponding Reactome human Poll II transcription elongation event. The details specific to HIV-1 transcription elongation are described below. In the absence of the HIV-1 Tat protein, the RNA Pol II complexes associated with the HIV-1 template are non-processive. RNA Pol II is arrested after promoter clearance by the negative transcriptional elongation factors DSIF and NELF as occurs during early elongation of endogenous templates (Wada et al, 1998; Yamaguchi et al. 1999). This arrest cannot be overcome by P-TEFb mediated phosphorylation in the absence of Tat however, and elongation aborts resulting in the accumulation of short transcripts (Kao et al., 1987).
Wada, T, Takagi, T, Yamaguchi, Y, Ferdous, A, Imai, T, Hirose, S, Sugimoto, S, Yano, K, Hartzog, GA, Winston, F, Buratowski, S, Handa, H
Kao, SY, Calman, AF, Luciw, PA, Peterlin, BM
Yamaguchi, Y, Takagi, T, Wada, T, Yano, K, Furuya, A, Sugimoto, S, Hasegawa, J, Handa, H
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