PRLR-bound STAT5 is phosphorylated

Stable Identifier
R-HSA-1671691
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Co-immunoprecipitation of rat Stat5 and Prlrs mutated to have a single intracellular tyrosine suggests that phosphorylation of these tyrosines is required for Stat5 binding and leads to Stat5 tyrosine phosphorylation (Pezet et al. 1997). STAT1 and STAT3 have both been reported to be activated by PRLR (DaSilva et al. 1996), but the region(s) of PRLR required for activation of these Stats remains poorly documented.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane]
Physical Entity
Activity
Inferred From
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Reviewed
Created