PRLR-bound STAT5 is phosphorylated

Stable Identifier
R-HSA-1671691
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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PRLR-bound STAT5 is phosphorylated
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Co-immunoprecipitation of rat Stat5 and Prlrs mutated to have a single intracellular tyrosine suggests that phosphorylation of these tyrosines is required for Stat5 binding and leads to Stat5 tyrosine phosphorylation (Pezet et al. 1997). STAT1 and STAT3 have both been reported to be activated by PRLR (DaSilva et al. 1996), but the region(s) of PRLR required for activation of these Stats remains poorly documented.

Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane]
Physical Entity
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Inferred From
Prlr-bound Stat5 is phosphorylated (Rattus norvegicus)
Authored
Jupe, S  (2011-06-13)
Reviewed
Goffin, V  (2011-11-08)
Created
Jupe, S  (2011-10-17)