Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Human immunodeficiency virus 1
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Formation of phosphodiester bonds nine and ten creates RNA products, which do not dissociate from the RNA pol II initiation complex. The transcription complex has enter the productive elongation phase. TFIIH and ATP-hydrolysis are required for efficient promoter escape. The open region (“transcription bubble”) expands concomitant with the site of RNA-extension. The region upstream from the transcription start site (-9 to -3) collapses to the double-stranded state. TFIIH remains associated to the RNA pol II initiation complex.

Literature References
PubMed ID Title Journal Year
9405375 Three transitions in the RNA polymerase II transcription complex during initiation.

Holstege, FC, Fiedler, U, Timmers, HT

EMBO J 1998
7601352 Recycling of the general transcription factors during RNA polymerase II transcription.

Zawel, L, Kumar, KP, Reinberg, D

Genes Dev 1995
Catalyst Activity

DNA-directed 5'-3' RNA polymerase activity of RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm]

Inferred From
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
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