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Reactome Pathway Database

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HIV-1 initiation complex with phosphodiester-PPi intermediate

Stable Identifier
R-HSA-167106
Type
Complex
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
    • Infectious disease (Homo sapiens)
      • HIV Infection (Homo sapiens)
        • HIV Life Cycle (Homo sapiens)
          • Late Phase of HIV Life Cycle (Homo sapiens)
            • Transcription of the HIV genome (Homo sapiens)
              • HIV Transcription Initiation (Homo sapiens)
                • Newly formed phosphodiester bond stabilized and PPi released (Homo sapiens)
                  • HIV-1 initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Homo sapiens)
                • Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP (Homo sapiens)
                  • HIV-1 initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Homo sapiens)
Participants
components
  • GTF2B [nucleoplasm] (Homo sapiens)
  • HIV-1 template DNA hybrid with phosphodiester-PPi intermediate [nucleoplasm] (Human immunodeficiency virus 1)
  • RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
  • TFIIA [nucleoplasm] (Homo sapiens)
  • TFIID [nucleoplasm] (Homo sapiens)
  • TFIIE [nucleoplasm] (Homo sapiens)
  • TFIIH [nucleoplasm] (Homo sapiens)
Participant Of
input
  • Newly formed phosphodiester bond stabilized and PPi released
output
  • Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP

 

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