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What is Reactome ?
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Scientific Advisory Board
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License Agreement
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Digital Preservation
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BDNF [extracellular region]
Stable Identifier
R-HSA-167028
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Brain-Derived Neurotrophic Factor
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
MECP2 regulates transcription of neuronal ligands (Homo sapiens)
BDNF gene transcription (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through CDK5 (Homo sapiens)
Activated NTRK2 binds CDK5 (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:CDK5:p35 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
CDK5 phosphorylates NTRK2 (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:p-Y15-CDK5:p35 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2 and CDK5 promote activation of RAC1 by TIAM1 (Homo sapiens)
BDNF:p-5Y,S479-NTRK2:p-Y829-TIAM1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2 binds TIAM1 (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2 phosphorylates CDK5 (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:CDK5:p35 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:p-Y15-CDK5:p35 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2 promotes TIAM1 phosphorylation (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2:p-Y829-TIAM1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
Activated NTRK2 signals through FRS2 and FRS3 (Homo sapiens)
Activated NTRK2 binds FRS2 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
Activated NTRK2 binds FRS3 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:FRS3 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2 activates RAS signaling through FRS2 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:PTPN11 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2 phosphorylates FRS2 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2 phosphorylates FRS3 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:FRS3 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS3 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2-phosphorylated FRS2 binds GRB2 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2-phosphorylated FRS2 binds PTPN11 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:PTPN11 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
Activated NTRK2 signals through FYN (Homo sapiens)
Activated FYN binds GRIN2B (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:GRIN2B [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
Activated NTRK2 binds FYN (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG-FYN-1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
FYN-mediated phosphorylation of GRIN2B (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:GRIN2B [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:p-Y1474-GRIN2B [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2 activates RAC1 (Homo sapiens)
DOCK3 activates RAC1 (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:DOCK3 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
DOCK3 binds FYN associated with NTRK2 (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:DOCK3 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2-bound FYN autophosphorylates (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer:MyrG-FYN-1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
Activated NTRK2 signals through PI3K (Homo sapiens)
Activated NTRK2 recruits PI3K (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2-activated PI3K generates PIP3 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
Activated NTRK2 signals through PLCG1 (Homo sapiens)
Activated PCLG1 dissociates from NTRK2 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2 phosphorylates PLCG1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:PLCG1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
p-Y817 of p-5Y-NTRK2 recruits PLCG1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:PLCG1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
Activated NTRK2 signals through RAS (Homo sapiens)
NTRK2 activates RAS signaling through SHC1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3):GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3) [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
NTRK2 phosphorylates SHC1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3) [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
SHC1 bound to activated NTRK2 recruits GRB2:SOS1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3) [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3):GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3) [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
p-Y516 of p-5Y-NTRK2 recruits SHC1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF activates NTRK2 (TRKB) signaling (Homo sapiens)
BDNF binds NTRK2 (TRKB) (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF-bound NTRK2 dimerizes (Homo sapiens)
BDNF:NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)
BDNF:NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
BDNF:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF homodimer [extracellular region] (Homo sapiens)
BDNF [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23560 BDNF
Gene Names
BDNF
Chain
signal peptide:1-18, chain:19-247, propeptide:19-128, chain:129-247
Reference Genes
BioGPS Gene:627 BDNF
COSMIC (genes):BDNF BDNF
CTD Gene:627 BDNF
dbSNP Gene:627 BDNF
ENSEMBL:ENSG00000176697 BDNF
HGNC:1033 BDNF
KEGG:hsa:627 BDNF
Monarch:627 BDNF
NCBI Gene:627 BDNF
OMIM:113505 BDNF
UCSC:P23560 BDNF
Reference Transcript
RefSeq:NM_001143807.1 BDNF
RefSeq:NM_170732.4 BDNF
RefSeq:NM_001143814.1 BDNF
RefSeq:NM_001143816.1 BDNF
RefSeq:NM_001143806.1 BDNF
RefSeq:NM_170733.3 BDNF
RefSeq:NM_001143808.1 BDNF
RefSeq:NM_001143811.1 BDNF
RefSeq:NM_001709.4 BDNF
RefSeq:NM_170731.4 BDNF
RefSeq:XM_011520280.2 BDNF
RefSeq:NM_001143810.1 BDNF
RefSeq:NM_001143813.1 BDNF
RefSeq:NM_001143805.1 BDNF
RefSeq:NM_001143809.1 BDNF
RefSeq:NM_001143812.1 BDNF
RefSeq:NM_170734.3 BDNF
RefSeq:NM_170735.5 BDNF
Participates
as an output of
BDNF gene transcription (Homo sapiens)
as a component of
BDNF homodimer [extracellular region] (Homo sapiens)
Other forms of this molecule
BDNF(1-247) [endoplasmic reticulum lumen]
Inferred To
BDNF [extracellular region]
(Bos taurus)
BDNF [extracellular region]
(Canis familiaris)
BDNF [extracellular region]
(Gallus gallus)
BDNF [extracellular region]
(Sus scrofa)
bdnf [extracellular region]
(Xenopus tropicalis)
Bdnf [extracellular region]
(Mus musculus)
Bdnf [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_733927.1
,
NP_733931.1
,
NP_001137282.1
,
NP_001137280.1
,
NP_001137279.1
,
NP_001137285.1
,
NP_001137277.1
,
NP_001137278.1
,
NP_001137284.1
,
NP_001137288.1
,
NP_001137286.1
,
XP_011518582.1
,
NP_001137281.1
,
NP_001137283.1
,
NP_733930.1
,
NP_733929.1
,
NP_733928.1
,
NP_001700.2
ENSEMBL
ENSP00000379307
,
ENST00000533131
,
ENSP00000437138
,
ENSP00000432727
,
ENST00000525528
,
ENST00000395986
,
ENST00000395981
,
ENST00000395983
,
ENST00000314915
,
ENST00000532997
,
ENSP00000349084
,
ENST00000356660
,
ENST00000525950
,
ENST00000418212
,
ENSP00000379309
,
ENST00000533246
,
ENSP00000379305
,
ENSP00000379302
,
ENSP00000435805
,
ENST00000438929
,
ENSP00000389345
,
ENSP00000435564
,
ENSP00000432035
,
ENSP00000432376
,
ENST00000439476
,
ENSP00000400502
,
ENSP00000320002
,
ENST00000395978
,
ENSG00000176697
,
ENST00000530861
,
ENSP00000414303
OpenTargets
ENSG00000176697
HPA
ENSG00000176697-BDNF
GeneCards
BDNF
PRO
P23560
Pharos - Targets
P23560
GlyGen
P23560
PDB
1BND
,
1B8M
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P34130 NTF4
1
NTF4 [extracellular region]
(R-HSA-167063)
0.718
6
UniProt:P20783 NTF3
1
NTF3 [extracellular region]
(R-HSA-167062)
0.59
3
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