SHC, complexed with TrkA, is tyrosine-phosphorylated

Stable Identifier
R-HSA-167019
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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SHC, complexed with TrkA, is tyrosine-phosphorylated
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Phosphorylation of Shc adapter proteins, and the concomitant recruitment of GRB2/SOS, results in the RAS-dependent, transient activation of ERKs, which is correlated with mitogenic and proliferative cell signalling. Prolonged activation of ERKs is instead regulated by a parallel pathway, involving CRK/C3G-dependent activation of the RAS-like GTPase RAP-1, and takes place in early endosomes.
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Output
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Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of Activated TrkA receptor:SHC [plasma membrane]

Physical Entity
Activated TrkA receptor:SHC [plasma membrane] (Homo sapiens)
Activity
transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Inferred From
Shc, complexed with TrkA, is Tyrosine-phosphorylated (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
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