Formation of Classical C3 convertase (C4b:C2a complex)

Stable Identifier
R-HSA-166795
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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Formation of Classical C3 convertase (C4b:C2a complex)
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C4b and C2a form a complex termed the classical pathway C3 convertase (Muller-Eberhard et al. 1967). C2a that fails to bind C4b is rapidly inactivated.

Literature References
PubMed ID Title Journal Year
6019133 Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement

Calcott, MA, Polley, MJ, Muller-Eberhard, HJ

J Exp Med 1967
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Authored
de Bono, B  (2004-08-04)
Reviewed
D'Eustachio, P  (2006-07-03)
Created
de Bono, B  (2005-09-16)
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