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HPSE(36-109) [lysosomal lumen]
Stable Identifier
R-HSA-1667006
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
HPSE, HPSE 8kDa, Heparanase, HPSE_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG degradation (Homo sapiens)
Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Homo sapiens)
HPSE dimer [lysosomal lumen] (Homo sapiens)
HPSE(36-109) [lysosomal lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y251 HPSE
Gene Names
HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1
Chain
signal peptide:1-35, chain:36-109, propeptide:110-157, chain:158-543
Reference Genes
BioGPS Gene:10855 HPSE
COSMIC (genes):HPSE HPSE
CTD Gene:10855 HPSE
dbSNP Gene:10855 HPSE
ENSEMBL:ENSG00000173083 HPSE
HGNC:5164 HPSE
KEGG:hsa:10855 HPSE
Monarch:10855 HPSE
NCBI Gene:10855 HPSE
OMIM:604724 HPSE
UCSC:Q9Y251 HPSE
Reference Transcript
RefSeq:NM_001098540.2 HPSE
RefSeq:NM_006665.5 HPSE
RefSeq:NM_001199830.1 HPSE
RefSeq:NM_001166498.2 HPSE
Other Identifiers
10855
11722662_a_at
11758873_a_at
16977537
219403_PM_s_at
219403_s_at
222881_PM_at
222881_at
2775995
2775996
2775997
2775998
2775999
2776000
2776001
2776002
2776003
2776004
2776005
2776008
2776009
2776014
2776015
2776016
2776018
2776019
2776020
2776021
2776022
2776023
45598_at
8101449
A_21_P0000064
A_23_P256107
A_24_P345866
GE80403
GO:0003824
GO:0004566
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005764
GO:0005765
GO:0005773
GO:0006029
GO:0006790
GO:0007155
GO:0007160
GO:0010575
GO:0016020
GO:0016787
GO:0016798
GO:0030163
GO:0030194
GO:0030200
GO:0030202
GO:0030305
GO:0030312
GO:0031012
GO:0033690
GO:0035580
GO:0042060
GO:0043202
GO:0043226
GO:0043231
GO:0045121
GO:0045545
GO:0048856
GO:0051797
GO:0051798
GO:0051897
GO:0055085
GO:0060055
GO:0061028
GO:0061042
GO:0071806
GO:1901135
HMNXSV003019122
HMNXSV003044719
ILMN_1779547
ILMN_2092850
PH_hs_0003210
TC04001347.hg
TC04002616.hg
g5729872_3p_a_at
g5880862_3p_at
Participates
as a component of
HPSE dimer [lysosomal lumen] (Homo sapiens)
Other forms of this molecule
HPSE(158-543) [specific granule lumen]
HPSE(36-109) [specific granule lumen]
HPSE(158-543) [extracellular region]
HPSE(36-109) [extracellular region]
HPSE(158-543) [lysosomal lumen]
Inferred To
Dmel\CG14309 [lysosomal lumen]
(Drosophila melanogaster)
hpse [lysosomal lumen]
(Danio rerio)
hpse [lysosomal lumen]
(Xenopus tropicalis)
HPSE(36-109) [lysosomal lumen]
(Gallus gallus)
HPSE(36-109) [lysosomal lumen]
(Mus musculus)
HPSE(36-109) [lysosomal lumen]
(Rattus norvegicus)
HPSE [lysosomal lumen]
(Bos taurus)
HPSE [lysosomal lumen]
(Canis familiaris)
HPSE [lysosomal lumen]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
2996
OpenTargets
ENSG00000173083
ENSEMBL
ENST00000509906
,
ENST00000405413
,
ENSP00000384262
,
ENSP00000308107
,
ENST00000513463
,
ENST00000512196
,
ENSP00000421365
,
ENSP00000423265
,
ENST00000311412
,
ENSP00000421038
HPA
ENSG00000173083-HPSE
ZINC - Substances
HPSE_HUMAN
ZINC target
Q9Y251
PRO
Q9Y251
Pharos - Targets
Q9Y251
GlyGen
Q9Y251
ZINC - Predictions - Purchasable
HPSE_HUMAN
HMDB Protein
HMDBP02807
PDB
7RG8
,
5LA4
,
5E8M
,
5E98
,
5E9B
,
7YI7
,
5LA7
,
7YJC
,
7PRT
,
5L9Y
,
5L9Z
,
8BAC
,
6ZDM
,
8CQI
,
8OHQ
,
8OHR
,
8JYG
,
7PR7
,
8B0B
,
5E9C
,
5E97
,
7PR8
,
8B0C
,
8E07
,
8E08
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