Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate (HS) from its HS proteoglycan (HSPG) (Toyoshima & Nakajima 1999). The formation of a heterodimer of 8kDa and 50kDa subunits cleaved from the 65kDa form is required for enzyme activity (Levy-Adam et al. 2003) and this proteolytic cleavage occurs in the lysosome (Goldshmidt et al. 2002). Acidic conditions within the lysosome optimises HPSE activity.
Geiger, B, Ilan, N, Irit, C, Vlodavsky, I, Feinstein, N, Katz, BZ, Aingorn, H, Goldshmidt, O, Zamir, E, Nadav, L
Ilan, N, Heinrikson, RL, Vlodavsky, I, Levy-Adam, F, Miao, HQ
Nakajima, M, Toyoshima, M
heparanase activity of HPSE dimer [lysosomal lumen]
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