Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate (HS) from its HS proteoglycan (HSPG) (Toyoshima & Nakajima 1999). The formation of a heterodimer of 8kDa and 50kDa subunits cleaved from the 65kDa form is required for enzyme activity (Levy-Adam et al. 2003) and this proteolytic cleavage occurs in the lysosome (Goldshmidt et al. 2002). Acidic conditions within the lysosome optimises HPSE activity.
Levy-Adam, F, Miao, HQ, Heinrikson, RL, Vlodavsky, I, Ilan, N
Goldshmidt, O, Nadav, L, Aingorn, H, Irit, C, Feinstein, N, Ilan, N, Zamir, E, Geiger, B, Vlodavsky, I, Katz, BZ
Toyoshima, M, Nakajima, M
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