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MASP1(20-699) [extracellular region]
Stable Identifier
R-HSA-166687
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
MASP1, MASP-1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
SARS-CoV-2 N binds MASP2 (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
N:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Conversion of C2 into C2a and C2b (Homo sapiens)
C4 activators [plasma membrane] (Homo sapiens)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
CL-LK:MASP1 dimer:MASP2 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
Conversion of C4 into C4a and C4b (Homo sapiens)
C4 activators [plasma membrane] (Homo sapiens)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
CL-LK:MASP1 dimer:MASP2 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
Creation of C4 and C2 activators (Homo sapiens)
Lectin pathway of complement activation (Homo sapiens)
Activation of MASPs (Homo sapiens)
MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
FCN3 ligands:FCN3 multimer:MASP1 dimer:MASP2 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
FCN3 oligomer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
CL-LK binds carbohydrates on target cell surface (Homo sapiens)
CL-LK:MASP1 dimer:MASP2 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
CL-LK:MASP1 dimer:MASP2 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
Ficolins bind to repetitive carbohydrate structures on the target cell surface (Homo sapiens)
Ficolin-1 binds to molecular patterns on the target cell surface (Homo sapiens)
FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
FCN1 ligands:FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
FCN1 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
Ficolin-2 binds to molecular patterns on the target cell surface (Homo sapiens)
FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
Ficolin-3 binds to molecular patterns on the target cell surface (Homo sapiens)
FCN3 ligands:FCN3 multimer:MASP1 dimer:MASP2 dimer:4xCa2+ [plasma membrane] (Homo sapiens)
FCN3 oligomer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
FCN3 oligomer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
Scavenging by Class A Receptors (Homo sapiens)
COLEC11 binds ligands (Homo sapiens)
COLEC11:Ligand [extracellular region] (Homo sapiens)
COLEC11:MASP1 [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
COLEC11:MASP1 [extracellular region] (Homo sapiens)
MASP1(20-699) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48740 MASP1
Gene Names
MASP1, CRARF, CRARF1, PRSS5
Chain
signal peptide:1-19, chain:20-699, chain:20-448, chain:449-699
Reference Genes
BioGPS Gene:5648 MASP1
COSMIC (genes):MASP1 MASP1
CTD Gene:5648 MASP1
dbSNP Gene:5648 MASP1
ENSEMBL:ENSG00000127241 MASP1
HGNC:6901 MASP1
KEGG:hsa:5648 MASP1
Monarch:5648 MASP1
NCBI Gene:5648 MASP1
OMIM:600521 MASP1
UCSC:P48740 MASP1
Reference Transcript
RefSeq:NM_001879.5 MASP1
RefSeq:NM_001031849.2 MASP1
RefSeq:NM_139125.3 MASP1
RefSeq:XM_017006872.1 MASP1
Participates
as a component of
COLEC11:MASP1 [extracellular region] (Homo sapiens)
MASP1 dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
MASP1(449-699) [extracellular region]
MASP1(20-448) [extracellular region]
Inferred To
MASP1(20-699) [extracellular region]
(Bos taurus)
MASP1(20-699) [extracellular region]
(Canis familiaris)
MASP1(20-699) [extracellular region]
(Gallus gallus)
MASP1(20-699) [extracellular region]
(Mus musculus)
MASP1(20-699) [extracellular region]
(Rattus norvegicus)
MASP1(20-699) [extracellular region]
(Sus scrofa)
MASP1(20-699) [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_624302.1
,
NP_001870.3
,
NP_001027019.1
,
XP_016862361.1
OpenTargets
ENSG00000127241
ENSEMBL
ENST00000169293
,
ENSP00000336792
,
ENSP00000169293
,
ENST00000707990
,
ENST00000707994
,
ENST00000296280
,
ENST00000337774
,
ENST00000707993
,
ENST00000707996
,
ENSP00000376264
,
ENSG00000127241
,
ENSP00000296280
,
ENSP00000517063
,
ENSP00000517064
,
ENST00000392472
,
ENSG00000291559
,
ENSP00000517062
,
ENSP00000517061
HPA
ENSG00000127241-MASP1
GeneCards
MASP1
PRO
P48740
Pharos - Targets
P48740
Orphanet
MASP1
PDB
7PQO
,
4AQB
,
3GOV
,
4IGD
,
3DEM
,
4IW4
,
4DJZ
,
4KKD
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