The bound receptor dimerizes

Stable Identifier
R-HSA-166538
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
The bound receptor dimerizes
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The binding of neurotrotrophin to TrkA receptors induce their dimerization to form receptor homodimers.

Literature References
PubMed ID Title Journal Year
1849459 The trk proto-oncogene encodes a receptor for nerve growth factor

Klein, R, Jing, SQ, Nanduri, V, O'Rourke, E, Barbacid, M

Cell 1991
10490030 Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

Wiesmann, C, Ultsch, MH, Bass, SH, de Vos, AM

Nature 1999
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
The bound receptor dimerizes (Bos taurus)
The bound receptor dimerizes (Canis familiaris)
The bound receptor dimerizes (Danio rerio)
The bound receptor dimerizes (Mus musculus)
The bound receptor dimerizes (Rattus norvegicus)
The bound receptor dimerizes (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Created
Jassal, B  (2005-09-08)