The bound receptor dimerizes

Stable Identifier
R-HSA-166538
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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The bound receptor dimerizes
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The binding of neurotrotrophin to TrkA receptors induce their dimerization to form receptor homodimers.

Literature References
PubMed ID Title Journal Year
10490030 Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

de Vos, AM, Bass, SH, Ultsch, MH, Wiesmann, C

Nature 1999
1849459 The trk proto-oncogene encodes a receptor for nerve growth factor

Jing, SQ, Klein, R, Barbacid, M, Nanduri, V, O'Rourke, E

Cell 1991
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Orthologous Events
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Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Created
Jassal, B  (2005-09-08)
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