The bound receptor dimerizes

Stable Identifier
R-HSA-166538
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The binding of neurotrotrophin to TrkA receptors induce their dimerization to form receptor homodimers.

Literature References
PubMed ID Title Journal Year
1849459 The trk proto-oncogene encodes a receptor for nerve growth factor

Klein, R, Jing, SQ, Nanduri, V, O'Rourke, E, Barbacid, M

Cell 1991
10490030 Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

Wiesmann, C, Ultsch, MH, Bass, SH, de Vos, AM

Nature 1999
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