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UCP1 [mitochondrial inner membrane]
Stable Identifier
R-HSA-166394
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Mitochondrial brown fat uncoupling protein 1, Thermogenin
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 (Homo sapiens)
UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
UCP1 [mitochondrial inner membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Mitochondrial Uncoupling (Homo sapiens)
The fatty acid cycling model (Homo sapiens)
FA anion diffuses laterally to UCP (Homo sapiens)
FA anion:UCP dimer "head-in" complex [mitochondrial inner membrane] (Homo sapiens)
UCP dimer [mitochondrial inner membrane] (Homo sapiens)
UCP [mitochondrial inner membrane] (Homo sapiens)
UCP1 [mitochondrial inner membrane] (Homo sapiens)
UCP dimer [mitochondrial inner membrane] (Homo sapiens)
UCP [mitochondrial inner membrane] (Homo sapiens)
UCP1 [mitochondrial inner membrane] (Homo sapiens)
FA anion flip-flops to the opposite surface (Homo sapiens)
FA anion:UCP dimer "head-out" complex [mitochondrial inner membrane] (Homo sapiens)
UCP dimer [mitochondrial inner membrane] (Homo sapiens)
UCP [mitochondrial inner membrane] (Homo sapiens)
UCP1 [mitochondrial inner membrane] (Homo sapiens)
FA anion:UCP dimer "head-in" complex [mitochondrial inner membrane] (Homo sapiens)
UCP dimer [mitochondrial inner membrane] (Homo sapiens)
UCP [mitochondrial inner membrane] (Homo sapiens)
UCP1 [mitochondrial inner membrane] (Homo sapiens)
UCP dimer [mitochondrial inner membrane] (Homo sapiens)
UCP [mitochondrial inner membrane] (Homo sapiens)
UCP1 [mitochondrial inner membrane] (Homo sapiens)
The FA anion diffuses away laterally from UCP (Homo sapiens)
FA anion:UCP dimer "head-out" complex [mitochondrial inner membrane] (Homo sapiens)
UCP dimer [mitochondrial inner membrane] (Homo sapiens)
UCP [mitochondrial inner membrane] (Homo sapiens)
UCP1 [mitochondrial inner membrane] (Homo sapiens)
UCP dimer [mitochondrial inner membrane] (Homo sapiens)
UCP [mitochondrial inner membrane] (Homo sapiens)
UCP1 [mitochondrial inner membrane] (Homo sapiens)
The proton buffering model (Homo sapiens)
Protons are translocated from the intermembrane space to the matrix (Homo sapiens)
UCP dimer [mitochondrial inner membrane] (Homo sapiens)
UCP [mitochondrial inner membrane] (Homo sapiens)
UCP1 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25874 UCP1
Gene Names
UCP1, SLC25A7, UCP
Chain
chain:1-307
Reference Genes
BioGPS Gene:7350 UCP1
COSMIC (genes):UCP1 UCP1
CTD Gene:7350 UCP1
dbSNP Gene:7350 UCP1
ENSEMBL:ENSG00000109424 UCP1
ENSEMBL_homo_sapiens_GENE:ENSG00000109424.4 UCP1
HGNC:12517 UCP1
KEGG Gene (Homo sapiens):7350 UCP1
Monarch:7350 UCP1
NCBI Gene:7350 UCP1
OMIM:113730 UCP1
UCSC:P25874 UCP1
Reference Transcript
RefSeq:NM_021833.4 UCP1
Other Identifiers
11732874_at
16980087
221384_PM_at
221384_at
2787082
2787083
2787084
2787085
2787086
2787087
2787088
2787089
2787090
7350
8102904
A_23_P30091
GE495741
GE59052
GO:0002024
GO:0005215
GO:0005525
GO:0005739
GO:0005740
GO:0005743
GO:0006351
GO:0006355
GO:0006357
GO:0006811
GO:0006839
GO:0008289
GO:0009266
GO:0009409
GO:0015078
GO:0016020
GO:0017077
GO:0019003
GO:0022857
GO:0030154
GO:0031667
GO:0031966
GO:0032555
GO:0032870
GO:0034220
GO:0034614
GO:0036041
GO:0043226
GO:0050873
GO:0055085
GO:0070417
GO:0071398
GO:0120162
GO:1901612
GO:1902600
GO:1903426
GO:1903495
GO:1990542
GO:1990845
HMNXSV003032298
ILMN_1677617
PH_hs_0013217
TC04001591.hg
TC04002755.hg
X51952_xpt1_at
X51953_at
X51954_at
g13259539_3p_at
Participates
as an output of
UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
as a member of
UCP [mitochondrial inner membrane] (Homo sapiens)
Inferred To
ucp1 [mitochondrial inner membrane]
(Xenopus tropicalis)
UCP1 [mitochondrial inner membrane]
(Bos taurus)
UCP1 [mitochondrial inner membrane]
(Canis familiaris)
UCP1 [mitochondrial inner membrane]
(Mus musculus)
UCP1 [mitochondrial inner membrane]
(Rattus norvegicus)
ucp4 [mitochondrial inner membrane]
(Danio rerio)
Cross References
RefSeq
NP_068605.1
Guide to Pharmacology - Targets
1066
OpenTargets
ENSG00000109424
GeneCards
P25874
HPA
ENSG00000109424-UCP1
Ensembl
ENSP00000262999
,
ENSG00000109424
,
ENST00000262999
PRO
P25874
Pharos - Targets
P25874
Orphanet
28947
PDB
8HBW
,
8HBV
,
8J1N
,
8G8W
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