Reactome | UCP1 [mitochondrial inner membrane]

UCP1 [mitochondrial inner membrane]

Stable Identifier

R-HSA-166394

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Mitochondrial brown fat uncoupling protein 1, Thermogenin

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P25874 UCP1

Gene Names

UCP1, SLC25A7, UCP

Chain

chain:1-307

Reference Genes

BioGPS Gene:7350 UCP1

COSMIC (genes):UCP1 UCP1

CTD Gene:7350 UCP1

dbSNP Gene:7350 UCP1

ENSEMBL:ENSG00000109424 UCP1

HGNC:12517 UCP1

KEGG:hsa:7350 UCP1

Monarch:7350 UCP1

NCBI Gene:7350 UCP1

OMIM:113730 UCP1

UCSC:P25874 UCP1

Reference Transcript

RefSeq:NM_021833.4 UCP1

Other Identifiers

11732874_at

16980087

221384_PM_at

221384_at

2787082

2787083

2787084

2787085

2787086

2787087

2787088

2787089

2787090

7350

8102904

A_23_P30091

GE495741

GE59052

GO:0002024

GO:0005215

GO:0005515

GO:0005525

GO:0005739

GO:0005740

GO:0005743

GO:0006355

GO:0006357

GO:0006839

GO:0008289

GO:0009266

GO:0009409

GO:0015078

GO:0017077

GO:0019003

GO:0022857

GO:0030154

GO:0031667

GO:0032555

GO:0032870

GO:0034220

GO:0034614

GO:0036041

GO:0043226

GO:0050873

GO:0055085

GO:0070417

GO:0071398

GO:0120162

GO:1901612

GO:1902600

GO:1903426

GO:1903495

GO:1990542

GO:1990845

HMNXSV003032298

ILMN_1677617

PH_hs_0013217

TC04001591.hg

TC04002755.hg

X51952_xpt1_at

X51953_at

X51954_at

g13259539_3p_at

Participates

as an output of

UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)

as a component of

UCP1 dimer [mitochondrial inner membrane] (Homo sapiens)

as a member of

UCP [mitochondrial inner membrane] (Homo sapiens)

Inferred To

ucp1 [mitochondrial inner membrane] (Danio rerio)

ucp1 [mitochondrial inner membrane] (Xenopus tropicalis)

UCP1 [mitochondrial inner membrane] (Bos taurus)

UCP1 [mitochondrial inner membrane] (Canis familiaris)

UCP1 [mitochondrial inner membrane] (Rattus norvegicus)

Ucp1 [mitochondrial inner membrane] (Mus musculus)

Cross References

Guide to Pharmacology - Targets

1066

ENSEMBL

ENSG00000109424, ENST00000262999, ENSP00000262999

OpenTargets

ENSG00000109424

GeneCards

UCP1

HPA

ENSG00000109424-UCP1

PRO

P25874

Pharos - Targets

P25874

PDB

8HBV, 8HBW, 8G8W, 8J1N

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60361 NME2P1	1	NME2P1 [cytosol] (R-HSA-6806876)	0.589	2