Reactome | FA anion diffuses laterally to UCP

FA anion diffuses laterally to UCP

Stable Identifier

R-HSA-166220

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

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A FA anion diffuses laterally within the membrane towards UCP. The membrane potential drives the FA anion to an energy well halfway up on UCP. The electric field created by the redox-linked proton ejection drives the head group to the energy well.

Literature References

PubMed ID	Title	Journal	Year
8576230	On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein Garlid, KD, Orosz, DE, Modriansky, M, Vassanelli, S, Jezek, P	J Biol Chem	1996
11709078	Mechanism of uncoupling protein action Garlid, KD, Jaburek, M, Jezek, P	Biochem Soc Trans	2001