Reactome | FA anion diffuses laterally to UCP

FA anion diffuses laterally to UCP

Stable Identifier

R-HSA-166220

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A FA anion diffuses laterally within the membrane towards UCP. The membrane potential drives the FA anion to an energy well halfway up on UCP. The electric field created by the redox-linked proton ejection drives the head group to the energy well.

Literature References

PubMed ID	Title	Journal	Year
11709078	Mechanism of uncoupling protein action Garlid, KD, Jaburek, M, Jezek, P	Biochem Soc Trans	2001
8576230	On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein Garlid, KD, Orosz, DE, Modriansky, M, Vassanelli, S, Jezek, P	J Biol Chem	1996