FA anion flip-flops to the opposite surface

Stable Identifier
R-HSA-166214
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FA anion flip-flops to the opposite surface
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The FA anion which was facing the matrix side of the inner mitochondrial membrane now flip-flops over to the intermembrane space-side of the membrane.

Literature References
PubMed ID Title Journal Year
8576230 On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein

Garlid, KD, Orosz, DE, Modriansky, M, Vassanelli, S, Jezek, P

J Biol Chem 1996
11709078 Mechanism of uncoupling protein action

Garlid, KD, Jaburek, M, Jezek, P

Biochem Soc Trans 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
anion transmembrane transporter activity of FA anion:UCP dimer "head-in" complex [mitochondrial inner membrane]
Physical Entity
FA anion:UCP dimer "head-in" complex [mitochondrial inner membrane]
Activity
anion transmembrane transporter activity (0008509)
Orthologous Events
FA anion flip-flops to the opposite surface (Bos taurus)
FA anion flip-flops to the opposite surface (Caenorhabditis elegans)
FA anion flip-flops to the opposite surface (Canis familiaris)
FA anion flip-flops to the opposite surface (Danio rerio)
FA anion flip-flops to the opposite surface (Dictyostelium discoideum)
FA anion flip-flops to the opposite surface (Drosophila melanogaster)
FA anion flip-flops to the opposite surface (Gallus gallus)
FA anion flip-flops to the opposite surface (Mus musculus)
FA anion flip-flops to the opposite surface (Rattus norvegicus)
FA anion flip-flops to the opposite surface (Saccharomyces cerevisiae)
FA anion flip-flops to the opposite surface (Sus scrofa)
FA anion flip-flops to the opposite surface (Xenopus tropicalis)
Created
Jassal, B  (2005-08-22)
Cite Us!