Reactome | TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2)

TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2)

Stable Identifier

R-HSA-166168

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endosome membrane

ReviewStatus

5/5

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TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2)

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TRIF-related adapter molecule (TRAM, also called TIRP or TICAM2) is 235 amino acids in length, and its TIR domain is most closely related to TRIF (and hence its name). Notably, both human and mouse TRAM contain a cysteine (C117 in humans) at the position where other adapters and TLRs have a conserved proline, although an adjacent proline (P116) is present. TRAM associates with TLR4 and TRIF, as well as the non-canonical NFkB kinases, IKK epsilon, and TBK1, which phosphorylate IRF3. TRAM provides specificity for the MyD88-independent component of TLR4 signaling.

Literature References

PubMed ID	Title	Journal	Year
15596121	Endotoxin recognition and signal transduction by the TLR4/MD2-complex Fitzgerald, KA, Rowe, DC, Golenbock, DT	Microbes Infect	2004
14556004	TRAM is specifically involved in the Toll-like receptor 4-mediated Yamamoto, M, Sato, S, Hemmi, H, Uematsu, S, Hoshino, K, Kaisho, T, Takeuchi, O, Takeda, K	Nat Immunol	2003
12471095	Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that Yamamoto, M, Sato, S, Mori, K, Hoshino, K, Takeuchi, O, Takeda, K	J Immunol	2002