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TRAM:TLR4:LY96:LPS:CD14
Stable Identifier
R-HSA-166163
Type
Complex
Species
Homo sapiens
Compartment
endosome membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-Like Receptors Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1,TRAF6-dependent induction of TAK1 complex (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Homo sapiens)
Auto-ubiquitination of TRAF3 (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAF3 binds TICAM1:activated TLR4 complex (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
IKK complex recruitment mediated by RIP1 (Homo sapiens)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Homo sapiens)
Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)
SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Activation of TAK1 complex bound to activated TLR4 complex (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Phosphorylated TAK1 leaves activated TLR receptor complex (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRIF-mediated programmed cell death (Homo sapiens)
Caspase-8 processing within TLR4 complex (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
RIP3 binds TRIF to mediate necroptosis (Homo sapiens)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
RIP3:RIP1:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRIF:activated TLR4 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4-induced ripoptosome assembly (Homo sapiens)
K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
via Death Receptors in the presence of ligand (Homo sapiens)
Caspase-8 processing within TLR4 complex (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Homo sapiens)
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
17726518
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
PLoS One
2007
15596121
Endotoxin recognition and signal transduction by the TLR4/MD2-complex
Microbes Infect
2004
Participants
components
2 x
MyrG-p-S16-TICAM2 [endosome membrane] (Homo sapiens)
TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
Participant Of
input
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)
output
TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2)
hasComponent
TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
Inferred To
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Bos taurus)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Danio rerio)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Rattus norvegicus)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Taeniopygia guttata)
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