Association of LBP with LPS

Stable Identifier
R-HSA-166015
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Lipopolysaccharide-binding protein (LBP) is a ~60-kDa serum glycoprotein which transfers LPS to both membrane-bound and soluble CD14. The LPS binding site of LBP consists of basic residues that bind the phosphorylated head of the bacterial lipid A.

LBP is an acute-phase opsonin that binds gram-negative bacteria and bacterial fragments and promote the interaction of coated bacteria with phagocytes.

Literature References
PubMed ID Title Journal Year
2477488 Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles

Wright, SD, Tobias, PS, Ulevitch, RJ, Ramos, RA

J Exp Med 1989
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