Association of LBP with LPS

Stable Identifier
R-HSA-166015
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Association of LBP with LPS
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Lipopolysaccharide-binding protein (LBP) is a ~60-kDa serum glycoprotein which transfers LPS to both membrane-bound and soluble CD14. The LPS binding site of LBP consists of basic residues that bind the phosphorylated head of the bacterial lipid A.

LBP is an acute-phase opsonin that binds gram-negative bacteria and bacterial fragments and promote the interaction of coated bacteria with phagocytes.

Literature References
PubMed ID Title Journal Year
2477488 Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles

Ramos, RA, Ulevitch, RJ, Wright, SD, Tobias, PS

J Exp Med 1989
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
BPI [extracellular region] (Homo sapiens)
Orthologous Events
Association of LBP with LPS (Bos taurus)
Association of LBP with LPS (Caenorhabditis elegans)
Association of LBP with LPS (Canis familiaris)
Association of LBP with LPS (Dictyostelium discoideum)
Association of LBP with LPS (Gallus gallus)
Association of LBP with LPS (Mus musculus)
Association of LBP with LPS (Rattus norvegicus)
Association of LBP with LPS (Sus scrofa)
Association of LBP with LPS (Xenopus tropicalis)
Authored
de Bono, B  (2005-08-16)
Reviewed
Gillespie, ME  (2010-11-30)
Granucci, F  (2012-11-13)
Zanoni, I  (2012-11-13)
Gay, NJ  (2006-04-24)
Created
de Bono, B  (2005-08-16)
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